Unraveling the relationship between high-sensitivity C-reactive protein and frailty

Unraveling the relationship between high-sensitivity C-reactive protein and frailty

Fuente:Bmc Geriatrics

Tipo de trabajo:Estudio de cohortes

Extracto: Our results suggest that reducing systemic inflammation is significant for developing strategies for frailty prevention and pre-frailty reversion in the middle-aged and elderly population.

Claves:Cohort study, Frailty, GWAS, Genetics, Hs-CRP

Cita:BMC Geriatr 2024 Mar 4; 24 (1) : 222.

Autor/es:Luo, Yu-Feng (a)
Cheng, Zi-Jian (b)

institución:(a) Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
(b) Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, Jiangsu, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12877-024-04836-2

Sex differences and age-related changes in vertebral body volume and volumetric bone mineral density at the thoracolumbar spine using opportunistic QCT.

Sex differences and age-related changes in vertebral body volume and volumetric bone mineral density at the thoracolumbar spine using opportunistic QCT.

Fuente:Frontiers in Endocrinology

Extracto: Sex differences in thoracolumbar vBMD were apparent before menopause, and disappeared after menopause, likely attributable to an accelerated and more profound vBMD decline in women at the thoracic spine. In patients without advanced spine degeneration, the overall volumetric changes in the vertebral body appeared subtle.

Claves:aging, bone geometry, menopause, opportunistic QCT, osteoporosis, sex-differences, vertebral fractures

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1352048.

Autor/es:Rühling, Sebastian (a)
Dittmann, Jonas (b)

institución:(a) Department of Diagnostic and Interventional Neuroradiology, TUM School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
(b) Department of Diagnostic and Interventional Neuroradiology, TUM School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Conflicto:The authors of this manuscript declare relationships with the following companies: JK, SR, and MH have equity in Bonescreen GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1352048

Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease.

Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease.

Fuente:Bmc Musculoskeletal Disorders

Extracto: The raised OPG and lower OPN in FDRs than in controls reflect an altered bone metabolism which could precede clinical disease phase. OPN and OPG could serve as markers of altered preclinical bone metabolism in FDRs of RA. US7 score might be a useful screening tool to identify 'at-risk' individuals.

Claves:First degree relatives, Osteopontin, Osteoprotegerin, Rheumatoid, Ultrasound

Cita:BMC Musculoskelet Disord 2024 Mar 5; 25 (1) : 195.

Autor/es:Soliman, Eiman (a)
Ohrndorf, Sarah (b)

institución:(a) Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
(b) Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12891-024-07291-7

Bone density of the cervical, thoracic and lumbar spine measured using Hounsfield units of computed tomography - results of 4350 vertebras.

Fuente:Bmc Musculoskeletal Disorders

Extracto: In our study, bone density decreased from cranial to caudal with higher values in the cervical spine. These data from the individual spinal segments may be helpful to comprehensively evaluate the status of the spine and to design a better preoperative plan before instrumentation.

Claves:Bone mineral density, Fracture, Hounsfield units, Osteoporosis, Spine

Cita:BMC Musculoskelet Disord 2024 Mar 6; 25 (1) : 200.

Autor/es:Simion, George (a)
Eckardt, Niklas (b)

institución:(a) Department of Neurosurgery, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany. george.simion@med.uni-jena.de.
(b) Department of Radiology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12891-024-07324-1

Bone mineral density in lower thoracic vertebra for osteoporosis diagnosis in older adults during CT lung cancer screening.

Bone mineral density in lower thoracic vertebra for osteoporosis diagnosis in older adults during CT lung cancer screening.

Fuente:Bmc Geriatrics

Extracto: Calculating the threshold of TBMD or normalizing TBMD to LBMD are both useful in identifying osteoporosis in older adults during CT lung cancer screening.

Claves:Computed tomography, Lung cancer, Osteoporosis, Quantitative computed tomography, Thoracic vertebral bone mineral density

Cita:BMC Geriatr 2024 Mar 6; 24 (1) : 237.

Autor/es:Hu, Nandong (a)
Wang, Miaomiao (b)

institución:(a) Department of Radiology, the Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong road, 210029, Nanjing, China.
(b) Department of Radiology, the Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong road, 210029, Nanjing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12877-024-04737-4

Community-embedded follow-up management intervention for geriatric primary care: a mixed-methods study of an integrated health services model.

Community-embedded follow-up management intervention for geriatric primary care: a mixed-methods study of an integrated health services model.

Fuente:Bmc Health Services Research

Extracto: Community-embedded follow-up management meets the need for elderly patients with osteoporosis living alone. It helps to improve health perception, promote physical and mental health, and optimize the quality of life in this population. Personalized services and professional support are two major contributing factors to effective embedded follow-up management in the community.

Claves:Community services, Living alone, Older adults, Osteoporosis, Professional support

Cita:BMC Health Serv Res 2024 Mar 6; 24 (1) : 298.

Autor/es:Shi, Wenjing (a)
Wu, Lingling (b)

institución:(a) Xinglin College, Nantong University, 226019, Nantong, China.
(b) Department of Orthopedics, The Yancheng Clinical College of Xuzhou Medical University (The First People's Hospital of Yancheng), 224001, Yancheng, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12913-024-10804-8

A meta-analysis comparing the efficacy of mineralized collagen-polymethylmethacrylate and polymethylmethacrylate bone cements in the treatment of vertebral compression fractures.

A meta-analysis comparing the efficacy of mineralized collagen-polymethylmethacrylate and polymethylmethacrylate bone cements in the treatment of vertebral compression fractures.

Fuente:Plos One

Tipo de trabajo:Revisión sistemática

Extracto: Compared with PMMA bone cement, the application of MC-PMMA bone cement is advantageous in reducing postoperative complications (adjacent vertebral fracture rate, cement leakage rate), pain relief, and functional recovery in the long-term postoperative period (>6 months), but there is still a need for more high-quality randomized controlled studies to provide more adequate evidence.

Cita:PLoS One 2024; 19 (3) : e0299325.

Autor/es:Li, Song-Feng (a)
Li, Xi-Yong (b)

institución:(a) Department of Orthopaedics, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, P.R. China.
(b) Graduate School, Changzhi Medical College, Changzhi, P.R. China.

Conflicto:The authors declare that they have no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299325

The changes of blood-based inflammatory biomarkers after non-pharmacologic interventions for chronic low back pain

The changes of blood-based inflammatory biomarkers after non-pharmacologic interventions for chronic low back pain

Fuente:Bmc Musculoskeletal Disorders

Tipo de trabajo:Revisión sistemática

Extracto: Results suggest a moderation of inflammatory biomarkers due to different non-pharmacologic interventions for CLBP, generally resulting in decreased pro-inflammatory markers such as TNF-α and IL-6 as well as increased anti-inflammatory markers such as IL-4, thus revealing the inhibition of inflammatory processes by different non-pharmacologic interventions. However, a limited number of high-quality studies evaluating similar interventions and similar biomarkers limits the conclusion of this review.

Claves:Anti-inflammatory cytokines, Interleukin, Pain management, Pro-inflammatory cytokines, Tumor necrosis factor alpha

Cita:BMC Musculoskelet Disord 2024 Mar 8; 25 (1) : 209.

Autor/es:Puerto Valencia, Laura Maria (a)
He, Yangyang (b)

institución:(a) Medical Sociology and Psychobiology, University of Potsdam, Potsdam, Germany.
(b) Medical Sociology and Psychobiology, University of Potsdam, Potsdam, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12891-024-07289-1

Quality appraisal of clinical practice guidelines addressing massage interventions using the AGREE II instrument.

Quality appraisal of clinical practice guidelines addressing massage interventions using the AGREE II instrument.

Fuente:Systematic Reviews

Tipo de trabajo:Consenso

Extracto: The overall quality of the included guidelines was low, and most of the guidelines were not "recommended". In future guideline updates, the existing evidence should be used, the professional composition of members of the expert group should be enriched, and patients' values and preferences should be fully considered. It is necessary to clearly propose recognizable recommendations and strengthen the rigor and standardization of guideline formulation. Thus, clear standard guidelines can be formulated to better guide clinical practice.

Claves:AGREE II, Consensus, Massage, Practice guideline, Quality assessment, Recommendation

Cita:Syst Rev 2024 Mar 8; 13 (1) : 83.

Autor/es:Fan, Mingyue (a)
Liu, Aolin (b)

institución:(a) The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
(b) The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.

Conflicto:The authors declare that they have no financial interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13643-024-02503-6

METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability.

METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability.

Fuente:International Journal of Medical Sciences

Extracto: Our study shed light on the critical roles of m(6)A on regulation of osteogenic differentiation in hPDLSCs and served novel therapeutic approaches in vital periodontitis therapy.

Claves:IGF2BP1, METTL3, Osteogenic differentiation, Runx2, hPDLSCs, m6A

Cita:Int J Med Sci 2024; 21 (4) : 664-673.

Autor/es:Sun, Xuefei (a)
Meng, Xiujiao (b)

institución:(a) Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
(b) Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Department of Endodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.

Conflicto:Competing Interests: The authors have declared that no competing interest exists.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Australia

Sitio web:http://dx.doi.org/10.7150/ijms.90485

Bone scan findings of Paget's disease of bone in patients with VCP Multisystem Proteinopathy 1.

Bone scan findings of Paget's disease of bone in patients with VCP Multisystem Proteinopathy 1.

Fuente:Scientific Reports

Extracto: However, diagnostic confirmation should be coupled with clinical history, biochemical analysis, and skeletal radiographs to facilitate early treatment and prevention complications, acknowledging its limited specificity.

Cita:Sci Rep 2024 Mar 11; 14 (1) : 5917.

Autor/es:Columbres, Rod Carlo Agram (a)
Din, Sarosh (b)

institución:(a) Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA, USA.
(b) College of Osteopathic Medicine, William Carey University, Hattiesburg, MS, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-54526-7

Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway.

Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway.

Fuente:Journal of Orthopaedic Surgery and Research

Extracto: GEN alleviated CHO-induced ER stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway.

Claves:ABCA1, Cholesterol, Endoplasmic reticulum stress, GLP-1R, Geniposide, Osteoporosis

Cita:J Orthop Surg Res 2024 Mar 11; 19 (1) : 179.

Autor/es:Zhong, Mingliang (a)
Wu, Zhenyu (b)

institución:(a) College of Rehabilitation, Gannan Medical University, Ganzhou, 341000, China.
(b) First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13018-024-04665-4

Is Silver Addition to Scaffolds Based on Polycaprolactone Blended with Calcium Phosphates Able to Inhibit Candida albicans and Candida auris Adhesion and Biofilm Formation?

Is Silver Addition to Scaffolds Based on Polycaprolactone Blended with Calcium Phosphates Able to Inhibit Candida albicans and Candida auris Adhesion and Biofilm Formation?

Fuente:International Journal of Molecular Sciences

Extracto: by using antimicrobial molecule-targeted delivery.

Claves:Candida albicans, Candida auris, Saos-2 cells’ osteogenic differentiation, anti-adhesive/antifungal properties, biofilm inhibition, calcium phosphates, poly(ε-caprolactone)-based biomaterial, silver

Cita:Int J Mol Sci 2024 Feb 28; 25 (5)

Autor/es:Menotti, Francesca (a)
Scutera, Sara (b)

institución:(a) Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy.
(b) Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25052784

Bone Health Impairment in Patients with Hemoglobinopathies: From Biological Bases to New Possible Therapeutic Strategies.

Fuente:International Journal of Molecular Sciences

Extracto: Therefore, here we will discuss the alteration of bone metabolism in patients with hemoglobinopathies and the possible therapeutic strategies to contain and/or counteract bone health impairment in these patients, taking into consideration not only the pharmacological treatments already used in the clinical armamentarium, but also the new possible therapeutic strategies.

Claves:alteration of bone metabolism, hemoglobinopathies, osteoporosis (OP), sickle cell disease (SCD), thalassemia

Cita:Int J Mol Sci 2024 Mar 1; 25 (5)

Autor/es:Di Paola, Alessandra (a)
Marrapodi, Maria Maddalena (b)

institución:(a) Department of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
(b) Department of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25052902

The Role of Glutathione in the Management of Cell-Mediated Immune Responses in Individuals with HIV.

Fuente:International Journal of Molecular Sciences

Extracto: We aim to review the current literature regarding the role of GSH in cell-mediated immune responses in individuals with HIV- and AIDS-defining illnesses.

Claves:HIV, HIV-associated neurodegenerative diseases, N-acetylcysteine, T cells, antioxidants, cell-mediated immunity, free radicals, interleukins

Cita:Int J Mol Sci 2024 Mar 3; 25 (5)

Autor/es:Lin, Nicole (a)
Erdos, Thomas (b)

institución:(a) College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
(b) College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25052952

Sphingolipid-Induced Bone Regulation and Its Emerging Role in Dysfunction Due to Disease and Infection.

Fuente:International Journal of Molecular Sciences

Extracto: However, deciphering the biochemical and molecular mechanisms of this diverse and extremely complex sphingolipidome, both in terms of bone health and disease, is considered the next frontier in the field.

Claves:bone, disease, infection, osteoporosis, sphingolipids

Cita:Int J Mol Sci 2024 Mar 5; 25 (5)

Autor/es:Seal, Anouska (a)
Hughes, Megan (b)

institución:(a) Biionix Cluster, University of Central Florida, Orlando, FL 32827, USA.
(b) School of Biosciences, Cardiff University, Cardiff CF10 3AT, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25053024

Novel Biomarkers of Bone Metabolism.

Novel Biomarkers of Bone Metabolism.

Fuente:Nutrients

Extracto: The aim of this review is to comprehensively examine some of the emerging biomarkers in mineral metabolism and their correlation with bone mineral density, fracture risk, and vascular calcification as well as their potential use in clinical practice.

Claves:biomarker, bone mineral density, chronic kidney disease, vascular calcification

Cita:Nutrients 2024 Feb 22; 16 (5)

Autor/es:Fernández-Villabrille, Sara (a)
Martín-Carro, Beatriz (b)

institución:(a) Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain.
(b) Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS), RICORS2040 (Kidney Disease), 28040 Madrid, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16050605

High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants (HIDVID Trial): Study Protocol for a Randomized Controlled Study.

Fuente:Nutrients

Extracto: The aim of this study is to evaluate the efficacy of monitored vitamin D supplementation in a group of preterm infants and ascertain if a high initial dosage of monitored vitamin D supplementation can decrease the occurrence of neonatal sepsis and metabolic bone disease.

Claves:infant, interleukin-6, osteopenia, parathyroid hormone, premature, sepsis, vitamin D

Cita:Nutrients 2024 Feb 29; 16 (5)

Autor/es:Paw, Dominika (a)
Bokiniec, Renata (b)

institución:(a) Department of Neonatology and Neonatal Intensive Care, Medical University of Warsaw, 00-315 Warsaw, Poland.
(b) Department of Neonatology and Neonatal Intensive Care, Medical University of Warsaw, 00-315 Warsaw, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16050700

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol.

Fuente:Nutrients

Extracto: In this context, resveratrol is also known for its unique role as an epigenetic modifier in the regulation of essential signaling processes-both due to its catabolic effect on BC and its anabolic effect on bone tissue.

Claves:bone metabolism, breast cancer, epigenetics, inflammation, osteoporosis, resveratrol

Cita:Nutrients 2024 Feb 29; 16 (5)

Autor/es:Meyer, Christine (a)
Brockmueller, Aranka (b)

institución:(a) Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Pettenkoferstr. 11, 80336 Munich, Germany.
(b) Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Pettenkoferstr. 11, 80336 Munich, Germany.

Conflicto:The authors declare the absence of conflicts of interest with respect to the present manuscript.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16050708

H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study.

H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study.

Fuente:Bmc Infectious Diseases

Extracto: Our study provides evidence for causal effects of H. pylori infection on osteoporosis. H. pylori may affect osteoporosis through serum albumin, high-density lipoprotein, fasting blood glucose and vitamin D.

Claves:Helicobacter pylori, Fasting blood glucose, High-density lipoprotein, Mendelian randomization, Osteoporosis, Serum albumin, Vitamin D

Cita:BMC Infect Dis 2024 Mar 12; 24 (1) : 305.

Autor/es:Zhang, Ling (a)
Zhang, Daya (b)

institución:(a) Department of Hospital infection management, LinYi people's Hospital, LinYi, Shandong Province, China.
(b) Graduate School of Hainan Medical University, Haikou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09196-1