Extracellular vesicle dynamics in COPD: understanding the role of miR-422a, SPP1 and IL-17 A in smoking-related pathology.

Extracellular vesicle dynamics in COPD: understanding the role of miR-422a, SPP1 and IL-17 A in smoking-related pathology.

Fuente:Bmc Pulmonary Medicine

Extracto: The differential gene analysis of Chip GSE38974-GPL7723 and the retrieval results from the Vesiclepedia database identified candidate miRs, specifically miR-422a. Further analysis involved the intersection of predictions from TargetScan, miRWalk, and RNA22 databases, gene search on COPD-related genes from the GeneCards database, WGCNA analysis from Chip GSE38974-GPL4133, and differential gene analysis, combined with KEGG functional enrichment analysis and protein interaction analysis. Ultimately, the target gene SPP1 and its upstream regulatory gene miR-422a were selected. KEGG functional enrichment analysis on mRNAs correlated with SPP1 revealed the involvement of the IL-17 signaling pathway. In vitro experiments showed that miR-422a targeted inhibition suppressed the expression of SPP1 in myofibroblast cells, inhibiting differentiation phenotype. Furthermore, bronchial epithelial cells could compensate for myofibroblast differentiation phenotype under cigarette smoke extract (CSE) stress by altering the miR-422a content in their extracellular vesicles (EVs).

Claves:Bioinformatics, COPD, Extracellular vesicles, IL-17 signaling pathway, SPP1, miR-422a

Cita:BMC Pulm Med 2024 Apr 12; 24 (1) : 173.

Autor/es:Dai, Zhihui (a)
Lin, Li (b)

institución:(a) Department of Respiratory and Critical Care Medicine, Yongkang First People's Hospital, Hangzhou Medical College, No. 599 Jinshan West Road, 321300, Yongkang, Zhejiang Province, P. R. China.
(b) Department of Respiratory and Critical Care Medicine, Yongkang First People's Hospital, Hangzhou Medical College, No. 599 Jinshan West Road, 321300, Yongkang, Zhejiang Province, P. R. China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-02978-y

Vitamin D and Insulin-Dependent Diabetes

Vitamin D and Insulin-Dependent Diabetes

Fuente:Nutrients

Tipo de trabajo:Revisión sistemática

Extracto: Because T1DM may cause osteopenia, it is advisable that patients with new onset T1DM have adequate vitamin D stores.

Claves:beta-cell preservation, glycemic control, insulin-dependent diabetes mellitus, type 1 diabetes (T1DM), vitamin D, vitamin D metabolites

Cita:Nutrients 2024 Apr 3; 16 (7)

Autor/es:Dadon, Yuval (a)
Hecht Sagie, Lior (b)

institución:(a) Ministry of Health, Jerusalem 9101002, Israel.
(b) Ministry of Health, Jerusalem 9101002, Israel.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16071042

Superficial Acral Fibromyxoma on the Thumb-Nail Bed.

Fuente:Rhode Island Medical Journal (2013)

Extracto: Our case is unique due to the tumor location and the patient's prior long history of trauma to the tumor site.

Claves:digit, fibromyxoma, nail, neoplasm, superficial acral fibromyxoma

Cita:R I Med J (2013) 2024 Apr 1; 107 (4) : 16-18.

Autor/es:Diehl, Kyra (a)
Barber, Cara (b)

institución:(a) Western University of Health Sciences, College of Osteopathic Medicine, Pomona, CA.
(b) Silver Falls Dermatology, Salem, OR.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:

Factors associated with different types of hip fractures among elderly patients a tertiary hospital in Pahang: A retrospective cross-sectional study.

Fuente:The Medical Journal of Malaysia

Extracto: With increased longevity among Malaysian citizen, the number of hip fracture cases are growing and leading to other health-related problems such as disability, depression, and cardiovascular. Various preventive interventions for osteoporosis and falls should be implemented to reduce the incidence of hip fractures among older adults.

Cita:Med J Malaysia 2024 Mar; 79 (Suppl 1) : 117-121.

Autor/es:Mohd Yusoff, R (a)
Mulud, Z A (b)

institución:(a) Hospital Pengajar Universiti Sultan Zainal Abidin Kampus Gong Badak, Kuala Terengganu, Terengganu, Malaysia.
(b) Universiti Teknologi MARA, Faculty of Health Sciences, Centre for Nursing Studies, Puncak Alam Campus, Selangor, Malaysia. zamzaliza@uitm.edu.my.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Malasia

Sitio web:

Developing a framework for promoting interest and engagement of scholarship of teaching and learning for medical students.

Fuente:Medical Education Online

Tipo de trabajo:Orientaciones y guía

Extracto: Our study provides insights for developing a framework that other institutions can reference and build upon to educate and engage students in SoTL.

Claves:Scholarship of teaching and learning, academic medicine, medical education research, medical student research, student-faculty partnership

Cita:Med Educ Online 2024 Dec 31; 29 (1) : 2336332.

Autor/es:Bhattacharjee, Ritvik (a)
Reynolds, Austin (b)

institución:(a) College of Osteopathic Medicine, Sam Houston State University, Conroe, USA.
(b) College of Osteopathic Medicine, Sam Houston State University, Conroe, USA.

Conflicto:No potential conflict of interest was reported by the author(s).

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1080/10872981.2024.2336332

Retrospective analysis of scaphoid trapezium pyrocarbon implant intervention in STT arthritis: a 3-year follow-up study.

Fuente:Journal of Plastic Surgery and Hand Surgery

Extracto: Radiographic signs of carpal instability were common at the follow-up and the revision rate was high.

Cita:J Plast Surg Hand Surg 2024 Apr 2; 59 : 40-45.

Autor/es:Zander, Maria (a)
Ibsen-Sörensen, Allan (b)

institución:(a) Department of Hand Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden. maria.zander@vgregion.se.
(b) Department of Hand Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suecia

Sitio web:http://dx.doi.org/10.2340/jphs.v59.34985

Patients who received sleeve gastrectomy have lower plasma osteopontin levels than those who did not.

Fuente:Clinics (sao Paulo, Brazil)

Extracto: OPN and HGF are promising biomarkers that can be used to better understand and detect problems related to obesity. The fact that patients in the early post-SG period had lower plasma OPN and similar plasma HGF compared to non-surgical patients of similar age and gender with higher BMI may be another favorable and previously unknown metabolic effect of SG.

Claves:Hepatocyte growth factor, Osteopontin, Sleeve gastrectomy

Cita:Clinics (Sao Paulo) 2024; 79 : 100352.

Autor/es:Öztürk, Doğan (a)
Koca, Arzu Or (b)

institución:(a) University of Health Sciences, Ankara Atatürk Sanatoryum Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Electronic address: drdoganozturk@hotmail.com.
(b) University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Onkoloji Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1016/j.clinsp.2024.100352

Drug-induced liver injury as assessed by the updated Roussel Uclaf Causality Assessment Method following mild COVID-19 in a patient under anastrozole therapy-A case report.

Fuente:Cancer Reports (hoboken, N.j.)

Extracto: The presentation of this case is meant to alert physicians to a potential drug-induced liver injury following mild SARS-CoV-2 infection in patients under anastrozole medication.

Claves:COVID‐19, anastrozole, cholestatic, drug‐induced liver injury, hepatocellular, updated RUCAM

Cita:Cancer Rep (Hoboken) 2024 Apr; 7 (4) : e2028.

Autor/es:Lischka, Wolfgang (a)
Kriegshäuser, Gernot (b)

institución:(a) Private Practice, Gumpoldskirchen, Austria.
(b) Department of Medical Genetics, Yerevan State Medical University, Yerevan, Armenia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/cnr2.2028

Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers.

Fuente:Alzheimer's Research & Therapy

Extracto: WMHs and abnormalities in peripheral vascular markers were found in patients with bvFTD. These were found to be associated with the disease-specific pattern of neurodegeneration, indicating that vascular dysfunction may be involved in the pathogenesis of bvFTD. This warrants further confirmation by postmortem autopsy. Targeting the vascular pathway might be a promising approach for potential therapy.

Claves:Clinical measures, Frontotemporal dementia, Neurodegeneration, Vascular factor

Cita:Alzheimers Res Ther 2024 Apr 5; 16 (1) : 72.

Autor/es:Chu, Min (a)
Jiang, Deming (b)

institución:(a) Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
(b) Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13195-024-01422-x

Savi Scout Localization for Extrapelvic Endometriosis Resection.

Fuente:The American Journal of Case Reports

Extracto: Surgical removal of extrapelvic endometrioma lesions can be made difficult by varying levels of palpability or localizability due to a patient's menstrual cycle. The Savi Scout, most commonly used in breast mass localization, is a useful tool in guiding surgical excision of non-palpable or intermittently palpable extrapelvic endometrioma lesions.

Cita:Am J Case Rep 2024 Apr 6; 25 : e942581.

Autor/es:Raman, Alex G (a)
John, Vaana (b)

institución:(a) College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA.
(b) Graduate Medical Education, Community Memorial Health System, Ventura, CA, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.12659/AJCR.942581

Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the "microbiota-gut-joint" axis.

Fuente:Journal of Nanobiotechnology

Extracto: To sum up, our study indicated that GNPs exhibited anti-osteoarthritis effects via modulating the interaction of "microbiota-gut-joint" axis, which might provide promising therapeutic strategies for OA.

Claves:Anti-inflammatory effects, Gold nanoparticles (GNPs), Gut microbiota, Osteoarthritis (OA), Short-chain fatty acid (SCFA) metabolism

Cita:J Nanobiotechnology 2024 Apr 8; 22 (1) : 157.

Autor/es:Deng, Zihan (a)
Yang, Chuan (b)

institución:(a) Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
(b) Department of Biomedical Materials Science, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12951-024-02447-y

[Vertebral fractures combined with prolonged activated partial prothrombin time

Fuente:Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences

Tipo de trabajo:Caso clínico

Extracto: Therefore, for patients with autoimmune diseases with prolonged APTT in the perioperative period, doctors need to carefully identify the actual cause and carry out targeted treatment in order to minimize the risk of surgical and perioperative complications and bring satisfactory treatment results to the patients.

Claves:Activated partial thromboplastin time, Lupus anticoagulants, Osteoporosis, Vertebral compression fractures

Cita:Beijing Da Xue Xue Bao Yi Xue Ban 2024 Apr 18; 56 (2) : 371-374.

Autor/es:Bai, Xinzhu (a)
He, Jinhui (b)

institución:(a) Department of Trauma and Orthopaedics, Peking University People's Hospital; National Center for Trauma Medicine, Beijing 100044, China.
(b) Department of Trauma, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie 551799, Guizhou, China.

Conflicto:利益冲突  所有作者均声明不存在利益冲突。

Formato:Informe impreso

Idioma:chi

País de fuente:China

Sitio web:

A Study on Intelligent Optical Bone Densitometry.

Fuente:Ieee Journal of Translational Engineering in Health and Medicine

Extracto: Our prediction rate had an error margin below 10% for the wrist and below 20% for the hip and spine bone density.

Claves:Bone mineral density, deep learning, multi-linear regression, near infrared imaging, osteoporosis, osteoporosis screening device

Cita:IEEE J Transl Eng Health Med 2024; 12 : 401-412.

Autor/es:Meitei, Takhellambam Gautam (a)
Chang, Wei-Chun (b)

institución:(a) Department of PhotonicsCollege of Electrical and Computer EngineeringNational Yang Ming Chiao Tung University Hsinchu 30010 Taiwan.
(b) Department of PhotonicsCollege of Electrical and Computer EngineeringNational Yang Ming Chiao Tung University Hsinchu 30010 Taiwan.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1109/JTEHM.2024.3368106

Peripheral extracellular vesicles in neurodegeneration: pathogenic influencers and therapeutic vehicles.

Fuente:Journal of Nanobiotechnology

Tipo de trabajo:Revisión

Extracto: The reference lists of selected articles were also examined to identify additional relevant studies.

Claves:Blood-brain barrier, Extracellular vesicles, Neurodegenerative disease, Peripheral-brain axis, Therapeutic delivery

Cita:J Nanobiotechnology 2024 Apr 12; 22 (1) : 170.

Autor/es:Liu, Xixi (a)
Shen, Lu (b)

institución:(a) Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
(b) Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12951-024-02428-1

Plasma serotonin precursors and metabolite are correlated with bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis.

Fuente:Journal of Orthopaedic Surgery (hong Kong)

Extracto: Plasma 5-HT precursors and metabolite negatively-correlate with BMD and positively-correlate with PINP/β-CTX in PMOP patients. Peripheral 5-HT precursors and metabolite level may be a new direction of treatment of PMOP and bone metabolism-related disorders.

Claves:5-hydroxyindoleacetic acid, 5-hydroxytryptophane, bone mineral density, osteoporosis, serotonin, tryptophan

Cita:J Orthop Surg (Hong Kong) 2024 Jan-Apr; 32 (1) : 10225536231187181.

Autor/es:Feng, Qinying (a)
Song, Xiaoyu (b)

institución:(a) Central Laboratory, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, China.
(b) Central Laboratory, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, China.

Conflicto:Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1177/10225536231187181

Skeletal muscle relaxants as adjunctive pain control following cardiothoracic surgery

Skeletal muscle relaxants as adjunctive pain control following cardiothoracic surgery

Fuente:Bmj Open

Tipo de trabajo:Revisión sistemática

Extracto: PROSPERO REGISTRATION NUMBER: CRD42023397917.

Claves:Adult intensive & critical care, Cardiothoracic surgery, INTENSIVE & CRITICAL CARE, PAIN MANAGEMENT, SURGERY, Thoracic surgery

Cita:BMJ Open 2024 Mar 25; 14 (3) : e079685.

Autor/es:Kabir, Shadman (a)
Whaley, Quinn (b)

institución:(a) College of Osteopathic Medicine, Nova Southeastern University Health Professions Division, Fort Lauderdale, Florida, USA.
(b) Miami Transplant Institute, Miami, Florida, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-079685

Caregiver perspectives on patient-focused drug development for Phelan-McDermid syndrome.

Caregiver perspectives on patient-focused drug development for Phelan-McDermid syndrome.

Fuente:Orphanet Journal of Rare Diseases

Tipo de trabajo:Estudio clínico

Extracto: Caregivers prioritize an improved quality of life for their loved ones characterized by improved cognitive function, improved communication, increased independence, and reduced risk of regression. With these caregiver priorities in mind, this report provides the FDA and the scientific community with a clear understanding of which aspects of PMS should influence the development of future therapeutics.

Claves:ASD, Autism spectrum disorder, Caregiver perspective, Drug development, PMS, Phelan-McDermid syndrome, SHANK3

Cita:Orphanet J Rare Dis 2024 Mar 26; 19 (1) : 134.

Autor/es:Gizzo, Luciana (a)
Bliss, Geraldine (b)

institución:(a) University of New England College of Osteopathic Medicine, Biddeford, ME, USA.
(b) CureSHANK, Beverly Hills, CA, USA.

Conflicto:Alexander Kolevzon is on the Advisory Board for the Klingenstein Third Generation Foundation, Ovid Therapeutics, David Lynch Foundation, ADNP Kids Research Foundation, and Ritrova Therapeutics and consults to Acadia, Alkermes, CureSHANK, Jaguar Therapeutics, PYC Therapeutics, GW Pharmaceuticals, Neuren Pharmaceuticals, Clinilabs Drug Development Corporation, Scioto Biosciences, and Biogen.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03141-w

Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders.

Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders.

Fuente:Cells

Extracto: This review highlights certain recent trends in neuroinflammatory responses and iPSC-derived brain cell applications in neuroinflammatory disorders.

Claves:Alzheimer’s disease, Gulf War Illness, Parkinson’s disease, human induced pluripotent stem cells, myalgic encephalomyelitis/chronic fatigue syndrome, neuroinflammation, traumatic brain injury

Cita:Cells 2024 Mar 14; 13 (6)

Autor/es:Cohen, Jessica (a)
Mathew, Annette (b)

institución:(a) Institute for Neuro-Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL 33328, USA.
(b) Institute for Neuro-Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL 33328, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/cells13060511

Vitamin D(3) deficiency and osteopenia in spastic paraplegia type 5 indicate impaired bone homeostasis.

Vitamin D(3) deficiency and osteopenia in spastic paraplegia type 5 indicate impaired bone homeostasis.

Fuente:Scientific Reports

Extracto: Sclerostin may be considered a therapeutic target and biomarker in upcoming therapeutical trials in SPG5.

Cita:Sci Rep 2024 Mar 27; 14 (1) : 7335.

Autor/es:Ehnert, Sabrina (a)
Hauser, Stefan (b)

institución:(a) Siegfried Weller Research Institute at the BG Unfallklinik Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, 72076, Tübingen, Germany.
(b) German Center of Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-53057-5

Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study.

Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study.

Fuente:Bmc Psychiatry

Extracto: This research sheds new light on the intricate connections between NDDs and fractures, offering valuable insights into potential risk factors and causal links. The bidirectional causal relationships between ADHD, ASD, and specific fractures highlight the need for comprehensive clinical approaches that consider both NDDs and physical well-being.

Claves:Attention deficit hyperactivity disorder, Autism spectrum disorder, Fracture and osteoporosis, Mendelian randomization, Neurodevelopmental disorders, Tourette syndrome

Cita:BMC Psychiatry 2024 Mar 27; 24 (1) : 232.

Autor/es:Li, Zefang (a)
Wu, Xueqiang (b)

institución:(a) Department of The First Clinical medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
(b) Department of Health Science, Shandong University of Traditional Chinese Medicine, Jinan, China. psywxq2023@126.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12888-024-05693-4