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indizadas por SIIC Data Bases, capturadas en las mismas colecciones o en diversas bases especializadas.
La creciente cantidad de artículos con Acceso Abierto (Open
Access) amplía la oferta de lectura pero a su vez también, entre
tanta abundancia, complica al lector en su encuentro con los estudios
fundamentales. Para facilitarlo, profesionales biomédicos de SIIC
consultan diariamente una profusa cantidad de documentos que nutrirán
Textos completos autorizados (TCA).
Las citas de la sección TCA enlazan de manera legal, autorizada y
gratuita con los textos completos (full text) publicados en
los sitios oficiales de sus respectivas fuentes.
SIIC creó, produjo y opera con exclusividad el software TCA para la
interpretación de los diversos campos documentales que integran la
estructura de un estudio: especialidad, modalidad del estudio,
fuente, fechas de publicación y selección, definición de la fuente,
limitaciones de consulta, resumen en castellano, etc.
Si bien la mayoría de los textos seleccionados corresponden a
artículos originales, revisiones y guías, los lectores también
encontrarán comentarios, entrevistas, notas periodísticas, cartas a
autores u otros textos precursores de debates o aclaratorios.
Sociedad Iberoamericana de Información Científica (SIIC) selects
complete quality-full texts which have been recently published in
renowned sources worldwide and are indexed by SIIC Data
Bases.
The increasing number of Open Access articles widens the reading offer
but, also, such myriad complicates the readers search of fundamental
articles. To facilitate this, SIIC biomedical professionals daily
consult a profuse amount of documents that will feed
Authorized Full Texts (TCA, Spanish acronym).
The citations of the AFT section link legally, authorized and free of
charge with the full texts published in the official web sites of
their corresponding sources.
SIIC created, produced and handles the AFT software that deciphers
the various documentary fields that form part of the structure of a
study: specialty, study style, source, publication and selection
dates, source definition, query limitations, summary in Spanish,
etc.
While most of the selected texts belong to original articles,
reviews, and guidelines, readers will also find commentaries,
interviews, journalistic reports, letters to authors or other texts
that may lead to discussions or clarifications.
Assessing Pulmonary Function in Children and Adolescents After Cancer Treatment
Assessing Pulmonary Function in Children and Adolescents After Cancer Treatment
Fuente:Jmir Research Protocols
Tipo de trabajo:Estudio de cohortes
Extracto:
This study will contribute to a comprehensive
understanding of pulmonary function in CCS and assess related risk factors, as
well as the utility of N(2)MBW compared to other PFTs. The results will assist in
the development of more targeted screening and risk-stratified follow-up care.
TRIAL REGISTRATION: ClinicalTrials.gov NCT04732273;
https://clinicaltrials.gov/study/NCT04732273. INTERNATIONAL REGISTERED REPORT
IDENTIFIER (IRRID): DERR1-10.2196/69743.
Claves:childhood cancer survivors, cohort study, late effects, multiple breath washout test, pulmonary toxicity, respiratory function tests
Cita:JMIR Res Protoc 2025 Apr 8; 14 : e69743.
Autor/es:Žarković, Maša (a) Schindera, Christina (b)
institución:(a) Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland. (b) Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
Markers of neutrophil activation and some immune and haematological indices in malaria infection during pregnancy.
Markers of neutrophil activation and some immune and haematological indices in malaria infection during pregnancy.
Fuente:Bmc Immunology
Extracto:
Malaria infection led to alterations in immune and haematological
parameters in this group, with mild and moderate malaria parasitaemia in the
study cohort. Although there were some significant differences, the assessed
values remained mostly within the normal range. Further studies in a larger
cohort assessing pregnant women infected with placental malaria and those with
fatal outcomes are important to further investigate the role of NETs in malaria
infection.
institución:(a) Immunology Department, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria. rc.chukwuanukwu@unizik.edu.ng. (b) Department of Internal Medicine 3, Uniklinikum Erlangen, Erlangen and Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. rc.chukwuanukwu@unizik.edu.ng.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Maternal counseling for preterm deliveries, assessing an effective method of counseling: A randomized trial.
Maternal counseling for preterm deliveries, assessing an effective method of counseling: A randomized trial.
Fuente:Plos One
Extracto:
Based on the results of our study, regardless of the method of
counseling there was no difference in knowledge assessment and comprehension of
information. However, there was an overall decrease in anxiety level of mothers
following any type of counseling. TRIAL REGISTRATION: ClinicalTrials.gov
NCT02707237.
institución:(a) Department of Pediatrics, Division of neonatology, John H Stroger Hospital of Cook County, Chicago, Illinois, United States of America. (b) Department of Pediatrics, Division of neonatology, John H Stroger Hospital of Cook County, Chicago, Illinois, United States of America.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identification of immune-related cervical cancer prognostic biomarkers and construction of prognostic model based on tumor microenvironment.
Identification of immune-related cervical cancer prognostic biomarkers and construction of prognostic model based on tumor microenvironment.
Fuente:European Journal of Medical Research
Extracto:
Immune-related prognostic biomarkers in CC include HLA-DMA, DMBT1,
CXCR6, CX3CL1, and SEMA3A. The risk score for the five genes is more accurate
than that for other clinical risk factors in predicting prognosis at 3 and
5 years. The higher the risk score is, the worse the prognosis of CC patients is.
Five prognostic biomarkers may participate in regulating TME through
chemokine-mediated signaling pathways and receptor-ligand interactions. These
findings provide new insights into the immunotherapy of CC.
institución:(a) Department of Obstetrics and Gynecology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. (b) Department of Obstetrics and Gynecology, The First Clinical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Early-Life Exposure to Acid-Suppressive Therapy and the Development of Celiac Disease Autoimmunity.
Early-Life Exposure to Acid-Suppressive Therapy and the Development of Celiac Disease Autoimmunity.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND
RELEVANCE: This retrospective study included both cohort and test-negative
case-control designs. In the cohort design, acid-suppressive therapy was
significantly associated with celiac disease autoimmunity. In the test-negative
case-control design, this association was not significant. These results suggest
a residual confounding by health care utilization in cohort designs studying
celiac disease and suggest a noncausal association between acid-suppressive
therapy and celiac disease autoimmunity.
Cita:JAMA Netw Open 2025 Apr 1; 8 (4) : e253376.
Autor/es:Achler, Tomer (a) Patalon, Tal (b)
institución:(a) School of Medicine, Tel Aviv University Faculty of Medical and Health Sciences, Tel Aviv, Israel. (b) Maccabi Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, Israel.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
[Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status and Diagnostic Challenges].
[Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status and Diagnostic Challenges].
Fuente:Acta Medica Portuguesa
Extracto:
The aim of this
article is to review the updated information on this issue and to provide the
experts' recommendations and practical guidance on the optimal management of
patients with soft tissue sarcomas, infantile fibrosarcoma, gastrointestinal
stromal tumors, and osteosarcoma.
institución:(a) EpiDoC Unit. Comprehensive Health Research Center (CHRC). NOVA Medical School. Universidade NOVA de Lisboa. Lisbon. Portugal. (b) Department of Medical Oncology. Hospital dos Lusíadas. Lisbon. Portugal.
Evaluating serum S-Equol, indoxyl sulfate, and TMAO in predicting urinary stones in children: a prospective study.
Evaluating serum S-Equol, indoxyl sulfate, and TMAO in predicting urinary stones in children: a prospective study.
Fuente:Urolithiasis
Extracto:
Children with urinary stone disease had significantly lower serum
S-equol and TMAO levels than healthy control subjects, suggesting a possible link
between these metabolites and stone formation.
institución:(a) Department of Pediatric Nephrology, Harran University Faculty of Medicine, Şanlıurfa, Turkey. aylinsam@gmail.com. (b) Department of Medical Physiology, Harran University Faculty of Medicine, Şanlıurfa, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisbon, Portugal. (b) Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Pediatric Surgery, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. (b) School of Clinical Medicine, Shandong Second Medical University, Jinan, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
There is
a clear lack of consensus for defining faecal impaction in children with
functional constipation. Despite the clinical, diagnostic and prognostic
importance of having a unified definition of faecal impaction, currently there
seems to be no universally accepted definition.
Claves:Gastroenterology
Cita:BMJ Paediatr Open 2025 Apr 7; 9 (1)
Autor/es:Gordon, Morris (a) Balda, Amber (b)
institución:(a) School of Medicine, University of Central Lancashire, Preston, UK Mgordon@uclan.ac.uk. (b) University of Miami Miller School of Medicine, Miami, Florida, USA.
Conflicto:Competing interests: CDL: Takeda, Bayer, Ironwood and Neuroaxis. MS: Abbvie and Ironwood. There are no competing interests for other authors.
How familial Mediterranean fever affects the characteristics of immunoglobulin a vasculitis in pediatric patients at the time of diagnosis?
How familial Mediterranean fever affects the characteristics of immunoglobulin a vasculitis in pediatric patients at the time of diagnosis?
Fuente:European Journal of Pediatrics
Extracto:
FMF may lead to more
severe clinical and laboratory findings and disease activity at the time of
IgAV diagnosis. The clinician should be aware that the course of IgAV may be
affected by the presence of FMF. TRIAL REGISTRATION: E2-24-6125, 21.01.2024,
retrospectively registered. WHAT IS KNOWN: • In patients with familial
Mediterranean fever (FMF), some vasculitides are more common and may affect the
course of vasculitis. WHAT IS NEW: • At the time of immunoglobulin A vasculitis
diagnosis, patients with FMF may have more system involvement, higher vasculitis
activation scores, and acute phase reactants and require more intensive treatment
than those without FMF.
Claves:Familial Mediterranean fever, Immunoglobulin A vasculitis, Pediatrics, Vasculitis
institución:(a) Division of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara Bilkent City Hospital, Bilkent, Ankara, 06800, Turkey. mehvesisiklar@gmail.com. (b) Division of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara Bilkent City Hospital, Bilkent, Ankara, 06800, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Adenosine-generating CD39(+) plasmablasts predispose to successful infliximab therapy in pediatric IBD.
Adenosine-generating CD39(+) plasmablasts predispose to successful infliximab therapy in pediatric IBD.
Fuente:Life Science Alliance
Extracto:
Our
results highlight the regulatory potential of CD39/CD73-expressing B cells in
pediatric IBD and suggest CD39(+) plasmablasts as a potential determinant of a
successful immunosuppressive therapy with IFX.
Cita:Life Sci Alliance 2025 Jun; 8 (6)
Autor/es:Schnell, Alexander (a) Schwarz, Benedikt (b)
institución:(a) Pediatric Gastroenterology and Hepatology, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany alexander.schnell@uk-erlangen.de. (b) Pediatric Gastroenterology and Hepatology, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Serratia marcescens and its role in Pink breast milk and upper GI bleeding in an infant
Serratia marcescens and its role in Pink breast milk and upper GI bleeding in an infant
Fuente:Bmc Infectious Diseases
Tipo de trabajo:Caso clínico
Extracto:
S.
marcescens should be considered a potential cause of gastrointestinal bleeding in
infants at risk. Although previously known to cause outbreaks in vulnerable
infants, pathogenicity in healthy infants is also possible. Maintaining strict
hygiene of feeding and breast milk pumping equipment is important to prevent
infections in infants.
Claves:Serratia marcescens, Infant, Pink breast milk, Upper Gastrointestinal bleeding
Cita:BMC Infect Dis 2025 Apr 8; 25 (1) : 482.
Autor/es:Osman, Rukhsar (a) Mbuki, Mayila (b)
institución:(a) Department of Paediatrics and Child Health, Aga Khan Hospital Tanzania, P.O. Box 2289, Dar Es Salaam, Tanzania. rukhsar.osman@scholar.aku.edu. (b) Department of Paediatrics and Child Health, Aga Khan University, P.O. Box 38129, Dar Es Salaam, Tanzania. rukhsar.osman@scholar.aku.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study.
Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study.
Fuente:Bmc Psychiatry
Tipo de trabajo:Metanálisis
Extracto:
Our findings
provide potential biomarkers for predicting and preventing PTSD, as well as
possible therapeutic targets for that. However, further research is needed to
confirm the clear mechanism.
institución:(a) Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China. (b) Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Pediatrics, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. (b) AMILI Pte Ltd, Singapore, 118261, Singapore.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Ovarian tissue cryopreservation for fertility preservation: a two-decade single-center experience with 451 children and adolescents.
Ovarian tissue cryopreservation for fertility preservation: a two-decade single-center experience with 451 children and adolescents.
Fuente:Reproductive Biology and Endocrinology Rb&e
Extracto:
Children and adolescents represent a small subset of OTC patients,
with indications linked to common pediatric malignancies. For active
storage ≥ 10 years, they store longer than adults, likely due to delayed
reproduction or awaiting in vitro growth / in vitro maturation in hematological
cases. Overall, adults store longer, but adolescent storage has risen over time
possibly due to higher child mortality and previously limited OTC use in younger
patients. Mean ovarian cortex surface data may guide pediatric tissue harvest
recommendations, with unilateral oophorectomy advised. Fertility preservation
counseling and cost coverage should be standard for pediatric patients undergoing
gonadotoxic treatment. A tailored approach to OTC indications is essential,
especially in high-mortality cancers like leukemia or sarcoma. Favorable
pregnancy rates observed, even without OTT, suggest possible OTC overutilization,
highlighting the need for individualized strategies and careful clinical
decision-making to balance risks and preserve reproductive potential.
Autor/es:Emrich, Norah L A (a) Einenkel, Rebekka (b)
institución:(a) Department of Gynecological Endocrinology and Reproductive Medicine, University Hospital of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. norah.emrich@ukbonn.de. (b) Department of Gynecological Endocrinology and Reproductive Medicine, University Hospital of Bonn, Venusberg Campus 1, Bonn, 53127, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Preparing medical students to incorporate scientific evidence into patient care: A cross-sectional study.
Preparing medical students to incorporate scientific evidence into patient care: A cross-sectional study.
Fuente:Plos One
Tipo de trabajo:Revisión sistemática
Extracto:
This study highlights important educational activities that prepare
medical students to incorporate scientific evidence into patient care: (i)
adequate assessment of key content regarding scholarly outcomes, including the
scientific foundation of medicine; (ii) learning activities about HTA and the
systematic review process; and (iii) hands-on application of EBM-related learning
activities integrated into clinical courses.
Cita:PLoS One 2025; 20 (4) : e0321211.
Autor/es:Wallerstedt, Susanna M (a) Garwicz, Martin (b)
institución:(a) Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. (b) HTA-centrum, Sahlgrenska University Hospital, Gothenburg, Sweden.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA. (b) Keck School of Medicine of USC, USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Neutralizing antibodies to SARS-CoV-2 variants of concern: a pediatric surveillance study.
Neutralizing antibodies to SARS-CoV-2 variants of concern: a pediatric surveillance study.
Fuente:Scientific Reports
Extracto:
These findings
emphasize the need for continued neutralizing antibody surveillance.
Cita:Sci Rep 2025 Apr 4; 15 (1) : 11588.
Autor/es:Fraser, Douglas D (a) Singh, Devika (b)
institución:(a) Pediatrics, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca. (b) Physiology and Pharmacology, Western University, London, ON, Canada. douglas.fraser@lhsc.on.ca.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Consecutive intrabronchial administration of Wharton's jelly-derived mesenchymal stromal cells in ECMO-supported pediatric patients with end-stage interstitial lung disease: a safety and feasibility study (CIBA method).
Consecutive intrabronchial administration of Wharton's jelly-derived mesenchymal stromal cells in ECMO-supported pediatric patients with end-stage interstitial lung disease: a safety and feasibility study (CIBA method).
Fuente:Stem Cell Research & Therapy
Tipo de trabajo:Estudio clínico
Extracto:
Direct intrabronchial administration of MSC in a patient on ECMO is
feasible and safe, and may be a new avenue to be assayed in ECMO patients with
inflammatory, immunological and infectious diseases of the lung.
Autor/es:Dominguez-Pinilla, Nerea (a) González-Granado, Luis Ignacio (b)
institución:(a) Pediatric Hematology and Oncology, Hospital 12 de Octubre, Madrid, Spain. (b) Immunodeficiencies Unit, Hospital 12 de Octubre, Madrid, Spain.
Conflicto:Declarations. Ethics approval: University Hospital 12 de Octubre (Madrid, Spain) Ethical Committee and AEMPS Permission number SLC59890178876, to the project entitled “Consecutive IntraBronchial Administration of Wharton’s Jelly-Derived Mesenchymal Stromal Cells in ECMO-Supported Pediatric Patients with End-Stage Interstitial Lung Disease: A Safety and Feasibility Study (CIBA Method)”. Informed consent: Informed consent was obtained from all subjects involved in the study. Conflict...
nflict of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki, and following advice from the European Medicines Agency (EMA) on Advanced Therapy Medicinal Products (ATMP), we obtained informed consent from the patient’s family, and Compassionate Use permission from the Spanish Agency of Medicines and Medical Devices (AEMPS) (Permission number SLC59890178876, August 16, 2023).
