Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications.

Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications.

Fuente:Scientific Reports

Extracto: Further research is warranted to improve accurate diagnosis of pediatric diabetes type.

Claves:Diabetes, Misdiagnosis, Pediatric diabetes, Type 1 diabetes, Type 2 diabetes

Cita:Sci Rep 2024 Apr 17; 14 (1) : 8876.

Autor/es:Tosur, Mustafa (a)
Huang, Xiaofan (b)

institución:(a) The Division of Diabetes and Endocrinology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 77030, USA. mustafa.tosur@bcm.edu.
(b) Children's Nutrition Research Center, Baylor College of Medicine, USDA/ARS, Houston, TX, 77030, USA. mustafa.tosur@bcm.edu.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58927-6

Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2.

Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2.

Fuente:Frontiers in Endocrinology

Extracto: Bone manifestations are prevalent, heterogeneous, and silent in CGL1 and CGL2. Osteolytic lesions are the most common, followed by osteosclerosis and pseudo-osteopoikilosis. Bone mass is high in most cases. There was no pain complaint related to bone lesions. Thus, systematic assessment of bone manifestations in CGL is essential. Studies are needed to better understand its pathogenesis and clinical consequences.

Claves:Berardinelli-Seip syndrome, bone, bone cyst, bone mineral density, lipodystrophy

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1326700.

Autor/es:Freire, Erika Bastos Lima (a)
Brasil d'Alva, Catarina (b)

institución:(a) Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Fortaleza, Brazil.
(b) Clinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará/EBSERH, Fortaleza, CE, Brazil.

Conflicto:RMMJ has received grant support and has served as an advisor and/or a consultant to Amryt Pharma, PTC Therapeutics and NovoNordisk. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1326700

Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry.

Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry.

Fuente:Italian Journal of Pediatrics

Extracto: Maintaining an evidence-based approach is essential to safeguard the well-being of transgender and gender diverse adolescents.

Claves:Adolescence, Gender dysphoria, Gender incongruence, Gender-affirming care, Gender-affirming hormone therapy, GnRH analogs, Pediatrics

Cita:Ital J Pediatr 2024 Apr 18; 50 (1) : 73.

Autor/es:Calcaterra, Valeria (a)
Tornese, Gianluca (b)

institución:(a) Pediatric Department, Buzzi Children's Hospital, Milano, Italy.
(b) Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

Conflicto:Giovanni Corsello is Editor in Chief of the Italian Journal of Pediatrics and Giorgio Perilongo is Associate Editor of the Italian Journal of Pediatrics. Other authors declare that they have no competing interests

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13052-024-01644-7

The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.

The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.

Fuente:Frontiers in Endocrinology

Tipo de trabajo:Estudio clínico

Extracto: Obesity-associated glycine deficiency impairs the human body's ability to eliminate endogenous and exogenous metabolites/compounds via the glycine conjugation pathway. This impairment is ameliorated when glycine supply is restored after bariatric surgery. These findings imply that dietary glycine supplementation could treat obesity-associated metabolic complications due to the accumulation of intramitochondrial toxic metabolites. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT04660513, identifier NCT04660513.

Claves:acylglycine, bariatric surgery, class III obesity, glycine conjugation, glycine deficiency

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1343738.

Autor/es:Tan, Hong Chang (a)
Hsu, Jean W (b)

institución:(a) Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
(b) Children's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1343738

Racial Discrimination and Metabolic Syndrome in Young Black Adults.

Racial Discrimination and Metabolic Syndrome in Young Black Adults.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: AND RELEVANCE: This study suggests that racial discrimination in late adolescence is associated with MetS among Black young adults through biobehavioral pathways. Thus, health interventions for MetS in Black adults will need to contend with sleep behaviors and inflammatory intermediaries as well as address and reduce exposure to racial discrimination to narrow disparities and promote health equity.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e245288.

Autor/es:Heard-Garris, Nia (a)
Yu, Tianyi (b)

institución:(a) Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
(b) Division of Advanced General Pediatrics and Primary Care, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.5288

Clinical features of plastic bronchitis in children after congenital heart surgery.

Clinical features of plastic bronchitis in children after congenital heart surgery.

Fuente:Italian Journal of Pediatrics

Tipo de trabajo:Estudio de cohortes

Extracto: Children with airway abnormalities or right ventricular dysfunction after CHS should be alerted to the development of PB. Pharmacological treatment such as anti-infection, corticosteroids, or improvement of right ventricular function is the basis of PB treatment, while fiberoptic bronchoscopy is an essential tool for the diagnosis and treatment of PB. ECMO assistance is a vital salvage treatment for recurrent critically ill PB patients.

Claves:Airway abnormalities, Children, Congenital heart surgery, Fiberoptic bronchoscopy, Plastic bronchitis

Cita:Ital J Pediatr 2024 Apr 19; 50 (1) : 74.

Autor/es:Zhu, Li-Min (a)
Li, Chun-Xiang (b)

institución:(a) Department of Cardiac Intensive Care Unit, Shanghai Children' s Medical Center, Shanghai Jiaotong University School of Medicine, 1678 Dongfang Road, 200127, Shanghai, PR China.
(b) Department of Cardiac Intensive Care Unit, Shanghai Children' s Medical Center, Shanghai Jiaotong University School of Medicine, 1678 Dongfang Road, 200127, Shanghai, PR China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13052-024-01650-9

Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis.

Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis.

Fuente:Respiratory Research

Extracto: Although further investigations and shared protocols are still needed, the safety of MSC therapy has been recurrently shown, and its potential in treating ARDS and preventing PF might represent a new therapeutic strategy.

Claves:ARDS, Acute respiratory distress syndrome, COVID-19, Mesenchymal stromal cells, Pulmonary fibrosis

Cita:Respir Res 2024 Apr 18; 25 (1) : 170.

Autor/es:Gazzaniga, Giulia (a)
Voltini, Marta (b)

institución:(a) SC Anestesia e Rianimazione 2, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, PV, 27100, Italy. giulia.gazzaniga@libero.it.
(b) Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. giulia.gazzaniga@libero.it.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12931-024-02795-1

Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity.

Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity.

Fuente:Italian Journal of Pediatrics

Extracto: Left ventricular remodeling is associated with the cardio-metabolic risk markers WC and WHR, but not with the adiposity index TMI among children with obesity.

Claves:Cardiovascular risk, Left ventricular hypertrophy, Left ventricular mass index, Pediatric obesity, Tri-ponderal mass index

Cita:Ital J Pediatr 2024 Apr 19; 50 (1) : 75.

Autor/es:Vizzuso, Sara (a)
Torto, Alberico Del (b)

institución:(a) Department of Pediatrics, Buzzi Children's Hospital, University of Milan, Milan, Italy. sara.vizzuso@asst-fbf-sacco.it.
(b) Centro Cardiologico Monzino IRCCS, Milan, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13052-024-01634-9

Kidney and urogenital abnormalities in Down syndrome

Fuente:Italian Journal of Pediatrics

Tipo de trabajo:Metanálisis

Extracto: This meta-analysis indicates that abnormalities of the kidney and urogenital tract, lower urinary tract dysfunctions, and a reduced kidney size present with an increased frequency in individuals with Down syndrome.

Claves:Down syndrome, Dysfunction of the urinary bladder, Kidney size, Meta-analysis, Urogenital abnormalities

Cita:Ital J Pediatr 2024 Apr 20; 50 (1) : 79.

Autor/es:Rossetti, Caterina Maria (a)
Simonetti, Giacomo D (b)

institución:(a) Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
(b) Faculty of Biomedical Sciences, Università della Svizzera Italiana, via Buffi 13, Lugano, Switzerland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13052-024-01636-7

Association between maternal cardiometabolic markers and fetal growth in non-complicated pregnancies: a secondary analysis of the PRINCESA cohort.

Association between maternal cardiometabolic markers and fetal growth in non-complicated pregnancies: a secondary analysis of the PRINCESA cohort.

Fuente:Scientific Reports

Extracto: These findings support the potential modulation of children's phenotype by maternal cardiometabolic conditions in pregnancies without medical complications.

Claves:Birth weight, Fetal growth, Fetal weight, Longitudinal study, Maternal cardiometabolic risk, Mexico, Pregnancy

Cita:Sci Rep 2024 Apr 20; 14 (1) : 9096.

Autor/es:Omaña-Guzmán, Isabel (a)
Ortiz-Hernández, Luis (b)

institución:(a) Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Mexico City, Mexico.
(b) Unidad de Vinculación Científica de la Facultad de Medicina, Instituto Nacional de Medicina Genómica, Universidad Nacional Autónoma de México, Periférico Sur 4809, Arenal Tepepan, 14610, Mexico City, CDMX, Mexico.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59940-5

Off-label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center.

Fuente:Cancer Medicine

Tipo de trabajo:Estudio de cohortes

Extracto: At our institution, ICI was most commonly prescribed in the relapsed/refractory setting to patients with metastatic disease. The treatment was generally well-tolerated in the pediatric population. The overall response rate was low, and the majority of patients eventually experienced disease progression. A few patients, however, had durable treatment responses. Further studies are needed to identify which pediatric patients are most likely to benefit from ICI.

Claves:experimental therapeutics, immune checkpoint, off‐label, pediatric cancer

Cita:Cancer Med 2024 Apr; 13 (8) : e7154.

Autor/es:Gikandi, Ajami (a)
Chi, Susan N (b)

institución:(a) Harvard Medical School, Boston, Massachusetts, USA.
(b) Harvard Medical School, Boston, Massachusetts, USA.

Conflicto:Steven G. DuBois has received consulting fees from Amgen, Bayer, and Jazz and travel expenses from Loxo Oncology, Roche, and Salarius. David S. Shulman has received consulting fees from Boehringer Ingelheim and serves on the scientific advisory board of Merlin Biotech. Allison F. O'Neill has received consulting fees from Fennec Pharmaceuticals and Skyline Therapeutics.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/cam4.7154

Evaluation of pediatric trauma score and pediatric age-adjusted shock index in pediatric patients admitted to the hospital after an earthquake.

Fuente:Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery Tjtes

Extracto: PTS and SIPA are important practical scoring systems that can be used to predict the severity of trauma, hospitalization, crush syndrome, and the clinical course in pediatric patients admitted to the hospital due to earthquake trauma.

Cita:Ulus Travma Acil Cerrahi Derg 2024 Apr; 30 (4) : 254-262.

Autor/es:Misirlioglu, Merve (a)
Alakaya, Mehmet (b)

institución:(a) Department of Pediatric Intensive Care, Mersin University Faculty of Medicine, Mersin-Türkiye.
(b) Department of Pediatric Intensive Care, Mersin University Faculty of Medicine, Mersin-Türkiye.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Turquía

Sitio web:http://dx.doi.org/10.14744/tjtes.2024.47835

Durability of Original Monovalent mRNA Vaccine Effectiveness Against COVID-19 Omicron-Associated Hospitalization in Children and Adolescents - United States, 2021-2023.

Fuente:Mmwr. Morbidity and Mortality Weekly Report

Extracto: Because of the low frequency of children who received updated COVID-19 vaccines and waning effectiveness of original monovalent doses, these data support CDC recommendations that all children and adolescents receive updated COVID-19 vaccines to protect against severe COVID-19.

Cita:MMWR Morb Mortal Wkly Rep 2024 Apr 18; 73 (15) : 330-338.

Autor/es:Zambrano, Laura D (a)
Newhams, Margaret M (b)

institución:Zambrano, Laura D (a)
Newhams, Margaret M (b)

Conflicto:All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Danielle M. Zerr reports institutional support from Merck and consulting fees from AlloVir. Melissa S. Stockwell reports institutional support from the National Institutes of Health (NIH). Mary Allen Staat reports institutional support from NIH, Pfizer, Cepheid, and Merck and... receipt of royalties from UpToDate for chapters on adoption and immunization. Jennifer E. Schuster reports institutional support from NIH, the Food and Drug Administration, and the State of Missouri, receipt of an honorarium from the Missouri chapter of the American Academy of Pediatrics (AAP) and participation on the advisory board of the Association of American Medical Colleges and the Association for Professionals in Infection Control and Epidemiology. Adrienne G. Randolph reports institutional support from NIH, royalties for UpToDate for work as a section editor, consulting fees from Inotrem, Inc. and ThermoFisher, Inc., receipt of honoraria from St. Jude Children’s Research Center and Volition, Inc., travel support from the International Sepsis Forum, participation on a data safety monitoring board for NIH and the Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia, serving as chair (2023–2024) of the International Sepsis Forum, and receipt of equipment from Illumina, Inc. (for institutional use). Pia S. Pannaraj reports institutional support from the National Institute on Allergy and Infectious Diseases, the National Institute of Child Health and Human Development, and AstraZeneca, receipt of honoraria from IDweek and Infectious Diseases in Children Symposium, payment for expert testimony from BBV Law Firm and Helsell Fetterman Law Firm, waiver of registration fee for IDweek meeting, uncompensated participation on three data safety monitoring boards 1) Phase II, Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial to Assess the Safety, Reactogenicity and Immunogenicity of One or Two Doses of Multimeric-001 (M-001) Followed by One or Two Doses of an Influenza A/H7N9 Vaccine, 2) Therapeutic Fecal Transplant on the Gut Microbiome in Children with Ulcerative Colitis, and 3) Safety of Fecal Transplant in maintenance of pediatric Crohn's disease), and uncompensated services as president of the California Immunization Coalition and the AAP Committee on Infectious Diseases. Kanokporn Mongkolrattanothai reports institutional support from Gilead. Samina S. Bhumbra reports travel support from CDC to present a plenary lecture at the Conference on Emerging Infectious Diseases. Kathleen Chiotos reports institutional support from the Agency for Healthcare Research and Quality and travel support from IDWeek (2022), Society for Healthcare Epidemiology of America (2022), and Pediatric Academic Societies (2022). Bria M. Coates reports institutional support from the National Heart, Lung, and Blood Institute and the American Lung Association, payment for expert testimony from Triplett Woolf Garretson, and participation on a Sobi Data Safety Monitoring Board. Thomas J. Connors reports grant support from NIH. Melissa L. Cullimore reports institutional support from NIH. Heidi R. Flori reports receipt of consulting fees from Lucira Health for advisory role for rapid diagnostic devices for COVID-19. Shira J. Gertz reports ownership of Pfizer stock. Ivan Gonzalez reports receipt of honoraria from the Florida Chapter of AAP for educational infection control initiatives and travel support from the Florida Chapter of AAP for regional conference attendance. Judith A. Guzman-Cottrill reports receipt of a consulting contract from the Oregon Health Authority. Natasha B. Halasa reports receipt of investigator-initiated grants from Sanofi, Quidel, and Merck. Charlotte V. Hobbs reports receipt of consulting fees from Dynamed.com and royalties as a content reviewer for UpToDate.com. Janet R. Hume reports institutional support from NIH and uncompensated participation on a data safety monitoring board for a study at the University of Minnesota (Magnesium sulfate as adjuvant analgesia and its effect on opiate use by postoperative transplant patients in the pediatric intensive care unit). Satoshi Kamidani reports institutional support from NIH, Pfizer, Moderna, Meissa, and Bavarian Nordic and receipt of honoraria from AAP. Michele Kong reports institutional support from NIH and uncompensated service on the Board of Directors for Jefferson County Department of Health, Callahan Eye Hospital, University of Alabama at Birmingham, and KultureCity. Regina M. Simeone reports payments received by her spouse from a previously managed Pfizer investment, which was sold in April 2023. No other potential conflicts of interest were disclosed.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.15585/mmwr.mm7315a2

Functional and oncological outcomes of patients with proximal humerus osteosarcoma managed by limb salvage.

Fuente:Journal of Orthopaedics and Traumatology Official Journal of The Italian Society of Orthopaedics and Traumatology

Extracto: Treatment of osteosarcoma of the proximal humerus by limb salvage and chemotherapy yields a good functional outcome. The method of reconstruction does not impact the resultant function. The 5-year survivorship of these patients is 65%. Younger patients have a better oncological outcome and an inferior functional outcome. LEVEL OF EVIDENCE: Level IV therapeutic study.

Claves:limb salvage, osteosarcoma, outcome, proximal humerus

Cita:J Orthop Traumatol 2024 Apr 18; 25 (1) : 18.

Autor/es:Sadek, Wael Mohamed Safwat (a)
Elshamly, Ibrahim Khairy Fayed (b)

institución:(a) Department of Orthopedics and Traumatology, Cairo University, Cairo, Egypt. Waelmsafwat89@gmail.com.
(b) Department of Orthopedics and Traumatology, Cairo University, Cairo, Egypt. Ibrahim.elshamly2008@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.1186/s10195-024-00756-4

IRE1 signaling increases PERK expression during chronic ER stress.

Fuente:Cell Death & Disease

Extracto: Our findings suggest cross talk between UPR branches aids adaptiveness thereby helping to support the plasticity of UPR signaling responses.

Cita:Cell Death Dis 2024 Apr 18; 15 (4) : 276.

Autor/es:Ong, Gideon (a)
Ragetli, Rosemund (b)

institución:(a) Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
(b) Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41419-024-06663-0

Neurobehavioral outcomes of neonatal asymptomatic congenital cytomegalovirus infection at 12-months.

Fuente:Journal of Neurodevelopmental Disorders

Extracto: These results indicate that at 12 months of age, infants with asymptomatic cCMV are not statistically different from controls in a number of neurobehavioral domains. Although follow-up is ongoing, these observations provide reassurance about neurobehavioral outcomes for infants with asymptomatic cCMV and inform the ongoing discussion around universal screening. Additional follow-up will be necessary to understand the longer-term outcomes of these children.

Claves:Congenital CMV infection, Intellectual disability, TORCH infections

Cita:J Neurodev Disord 2024 Apr 18; 16 (1) : 19.

Autor/es:Stoyell, Sally M (a)
Elison, Jed T (b)

institución:(a) Institute of Child Development, University of Minnesota, Minneapolis, MN, USA. stoye003@umn.edu.
(b) Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA. stoye003@umn.edu.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s11689-024-09533-0

Prevalence of overweight and obesity among adolescents living with HIV after dolutegravir - based antiretroviral therapy start in Kampala, Uganda.

Fuente:Aids Research and Therapy

Extracto: Our study found a prevalence of 7.3% of overweight and obesity in ALHIV after initiating DTG. We did not find any factor significantly associated with excessive weight gain in ALHIV on DTG. Nonetheless, we recommend ongoing routine monitoring of anthropometry and metabolic markers in ALHIV as DTG use increases globally, to determine the exact magnitude of excessive weight gain and to identify those at risk of becoming overweight or obese while taking the medication.

Claves:Adolescents, Dolutegravir, HIV, Uganda, Weight gain

Cita:AIDS Res Ther 2024 Apr 18; 21 (1) : 23.

Autor/es:Nakatudde, Irene (a)
Katana, Elizabeth (b)

institución:(a) Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda. b.irenaka@gmail.com.
(b) College of Health Sciences, Makerere University, Kampala, Uganda.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12981-024-00615-6

Bioinformatics-based discovery of biomarkers and immunoinflammatory targets in children with cerebral palsy: An observational study.

Fuente:Medicine

Tipo de trabajo:Orientaciones y guía

Extracto: Jak-STAT signaling pathway, mTOR signaling pathway, and related hub genes regulate immune cells and inflammatory factors and play an important role in the development and progression of CP.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37828.

Autor/es:Chen, Bo (a)
Wang, Ling (b)

institución:(a) Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China.
(b) Department of Rehabilitation Science, Hong Kong Polytechnic University, Hong Kong, China.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037828

Bone health and physical activity in adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study.

Fuente:Pediatric Rheumatology Online Journal

Extracto: Adolescents with JIA had lower total body aBMD and BMC compared with sex- and age-matched controls without JIA. Group differences in bone outcomes were not associated with the lower MVPA participation of adolescents with JIA. Despite this, physical activity should still be encouraged as it promotes physical well-being.

Claves:Bone, Juvenile idiopathic arthritis, Lean mass, Physical activity

Cita:Pediatr Rheumatol Online J 2024 Apr 19; 22 (1) : 45.

Autor/es:Vasil, Egi (a)
M Nesbitt, Colleen (b)

institución:(a) Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, T2N 1N4, Calgary, AB, Canada.
(b) McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada.

Conflicto:The authors report no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12969-024-00982-4

A novel variant in NSUN2 causes intellectual disability in a Chinese family.

Fuente:Bmc Medical Genomics

Extracto: Our study expands the genetic spectrum of NSUN2 mutations and helps to further define the genotype-phenotype correlations in MRT5.

Claves:NSUN2 gene, Genotype-phenotype correlation, Intellectual disability, Novel variant, Whole exome sequencing

Cita:BMC Med Genomics 2024 Apr 20; 17 (1) : 95.

Autor/es:Yang, Qi (a)
Zhang, Qiang (b)

institución:(a) Guangxi Key Laboratory of Birth Defects Research and Prevention, Guangxi Key Laboratory of Reproductive Health and Birth Defects Prevention, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, No. 59, Xiangzhu Road, Nanning, China.
(b) Department of Genetic and Metabolic Central Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12920-024-01883-x