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SIIC created, produced and handles the AFT software that deciphers
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Lesion volume and spike frequency on EEG impact perfusion values in focal cortical dysplasia: a pediatric arterial spin labeling study.
Lesion volume and spike frequency on EEG impact perfusion values in focal cortical dysplasia: a pediatric arterial spin labeling study.
Fuente:Scientific Reports
Extracto:
These observations may facilitate the interpretation of ASL findings, improving
treatment management, counselling, and prognostication in children with
FCD-related epilepsy.
Cita:Sci Rep 2024 Mar 31; 14 (1) : 7601.
Autor/es:Gennari, Antonio Giulio (a) Bicciato, Giulio (b)
institución:(a) Department of Neuropediatrics, University Children's Hospital Zurich, 75, 8032, Zurich, Switzerland. (b) MR-Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Assessing the risk of concurrent mycoplasma pneumoniae pneumonia in children with tracheobronchial tuberculosis: retrospective study.
Assessing the risk of concurrent mycoplasma pneumoniae pneumonia in children with tracheobronchial tuberculosis: retrospective study.
Fuente:Peerj
Extracto:
Compared to machine learning
approaches, the XGBoost model demonstrated superior predictive efficacy in
identifying pediatric patients at risk of concurrent TBTB and Mycoplasma
pneumoniae pneumonia. The model's identification of critical signatures provides
valuable insights into the pathogenesis of these conditions.
institución:(a) Department of Pediatrics, the Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China. (b) Department of Pediatrics, the Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
Fuente:Nature Communications
Extracto:
Our results thus provide insight into potentially
clinically relevant RNA-binding protein-dependent mechanisms of osteosarcoma.
Cita:Nat Commun 2024 Apr 1; 15 (1) : 2810.
Autor/es:Zhou, Yang (a) Ray, Partho Sarothi (b)
institución:(a) Molecular Medicine Partnership Unit (MMPU), Heidelberg University and European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. (b) Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. (b) Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical phenotype and genetic function analysis of a family with hypomyelinating leukodystrophy-7 caused by POLR3A mutation.
Clinical phenotype and genetic function analysis of a family with hypomyelinating leukodystrophy-7 caused by POLR3A mutation.
Fuente:Scientific Reports
Extracto:
This study indicates that the POLR3A p.Cys767Phe variant caused
increased expression of mutated POLR3A protein and abnormal expression of Pol III
transcripts, and the mutant POLR3A protein function was abnormal.
institución:(a) Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, China. (b) Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Stabilizing time and its predictors among 1-59 months old children managed for severe acute malnutrition during the humanitarian crisis in Tigray regional state of Ethiopia, 2023
Stabilizing time and its predictors among 1-59 months old children managed for severe acute malnutrition during the humanitarian crisis in Tigray regional state of Ethiopia, 2023
Fuente:Bmc Pediatrics
Tipo de trabajo:Estudio de cohortes
Extracto:
All the
outcome indicators for stabilization center are consistent with the SPHERE
association set of standards during humanitarian intervention. The hospital and
other concerned humanitarian organizations should focus on sustaining these
achievements as suhul hospital is the main treatment center for children
suffering from severe acute malnutrition in the northwest zone of Tigray regional
state. Further pre-post experimental studies which compare the stabilizing time
before and after crisis are recommended.
Claves:Emergency, Ethiopia, Severe acute malnutrition, Stabilizing time, Tigray
Cita:BMC Pediatr 2024 Apr 1; 24 (1) : 221.
Autor/es:Tesfay, Wagnew (a) Abay, Mebrahtu (b)
institución:(a) Medical Teams International (MTI), Shire Field Office, Nutrition Supervisor, Shire, Ethiopia. wagnew.tesfaye@gmail.com. (b) College of Health Sciences, Aksum University, Aksum, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical features of intussusception in children secondary to small bowel tumours: a retrospective study of 31 cases.
Clinical features of intussusception in children secondary to small bowel tumours: a retrospective study of 31 cases.
Fuente:Bmc Pediatrics
Extracto:
Lymphoma is the most common cause of intussusception in
pediatric patients with small bowel tumours, followed by adenoma. Small bowel
tumours in children tend to occur in the ileum. Therefore, the treatment of SBT
patients not only requires surgeons to address symptoms through surgery and
obtain tissue samples but also relies heavily on the expertise of pathologists
for accurate diagnosis. This has a significant impact on the overall prognosis of
these patients.
Claves:Children, Intussusception, Secondary, Small bowel tumours, Surgery
Cita:BMC Pediatr 2024 Apr 1; 24 (1) : 227.
Autor/es:Wang, Li (a) Zhang, Hanwen (b)
institución:(a) Department of Emergency Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. (b) Department of Emergency Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Factors associated with damages and repair costs of reusable flexible bronchoscopes in pediatrics in China.
Factors associated with damages and repair costs of reusable flexible bronchoscopes in pediatrics in China.
Fuente:Bmc Pediatrics
Extracto:
The failure rate in the pediatric flexible bronchoscopes was not high but the
repair costs were extremely high. The types and size of the flexible
bronchoscopes and work experience of the staff members responsible for
bronchoscope reprocessing were the possible factors associated with the failure
rate in the pediatric flexible bronchoscopes. It is advisable to further optimize
the central workflow and management mode for reprocessing the pediatric flexible
bronchoscopes, thereby extending their useful life and reducing costs.
Claves:Cause analysis, Central reprocessing, Common failure, Pediatric flexible bronchoscope
Cita:BMC Pediatr 2024 Apr 1; 24 (1) : 228.
Autor/es:Hu, Ruixue (a) Chen, Yanhua (b)
institución:(a) Department of Sterile Processing Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. (b) Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Anti-synthetase syndrome in a child with pneumomediastinum
Anti-synthetase syndrome in a child with pneumomediastinum
Fuente:Bmc Pulmonary Medicine
Tipo de trabajo:Revisión
Extracto:
ASS in children may combine with rapidly progressive interstitial lung disease
(RPILD) and pneumomediastinum. It is crucial to promptly identify concurrent
immunologic abnormalities during the outbreak of MP, particularly when the
disease exhibits rapid progression with ineffective conventional antibiotic
therapy.
Unusual presentation of miliary tuberculosis in a 12-year-old girl
Unusual presentation of miliary tuberculosis in a 12-year-old girl
Fuente:Bmc Pediatrics
Tipo de trabajo:Caso clínico
Extracto:
The results of this study showed that severe miliary TB may
occur even in a person who received the Bacille Calmette-Guérin (BCG) vaccine.
Claves:Miliary, Mycobacteria, Tuberculosis
Cita:BMC Pediatr 2024 Apr 1; 24 (1) : 223.
Autor/es:Kamali, Mahsa (a) Navaeifar, Mohammad Reza (b)
institución:(a) Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran. (b) Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Critical period of oxygen supplementation and invasive ventilation: implications for severe retinopathy of prematurity.
Critical period of oxygen supplementation and invasive ventilation: implications for severe retinopathy of prematurity.
Fuente:Italian Journal of Pediatrics
Extracto:
Amount of oxygen supplementation and/or invasive
ventilation during the first 7 weeks of life or up to 31 weeks PMA was associated
with development of severe ROP. This period might be candidate timing for strict
oxygen supplementation strategies in preterm infants, while concerns of mortality
with low oxygen supplementation should be further explored.
Claves:Hyperoxia, Invasive ventilation, Preterm infants, Retinopathy of Prematurity
Cita:Ital J Pediatr 2024 Apr 1; 50 (1) : 58.
Autor/es:Choi, Ho Jung (a) Shin, Baek Sup (b)
institución:(a) Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. (b) Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Neurophysiological Characteristics in Type II and Type III 5q Spinal Muscular Atrophy Patients: Impact of Nusinersen Treatment.
Neurophysiological Characteristics in Type II and Type III 5q Spinal Muscular Atrophy Patients: Impact of Nusinersen Treatment.
Fuente:Drug Design, Development and Therapy
Extracto:
Motor nerve amplitudes were significantly decreased in type II and
type III 5q SMA patients compared to healthy controls. Nusinersen treatment
showed better improvement in motor nerve amplitudes in younger age groups and
those with shorter disease duration, indicating a treatment-time dependence.
Claves:5q spinal muscular atrophy, Nusinersen, neurophysiology, peripheral motor nerve
Cita:Drug Des Devel Ther 2024; 18 : 953-965.
Autor/es:Li, Dan (a) Sun, Na (b)
institución:(a) Department of Pediatrics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. (b) Department of Pediatrics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement.
Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement.
Fuente:Frontiers in Immunology
Extracto:
This study
extends to NK cells an altered profile of TRAIL, Bcl-2, TNFR1, Fas, FasL, Bax,
Bim, and caspase-3 proteins in patients with jSLE, particularly in those with
active disease, positive anti-dsDNA, nephritis, and without neuropsychiatric
involvement. This change in apoptosis-related protein expressions may contribute
to the defective functions of NK cells and, consequently, to lupus development.
The full clarification of the role of NK cells in jSLE pathogenesis may pave the
way for new therapies like those of NK cell-based.
Autor/es:Liphaus, Bernadete L (a) Silva, Simone C (b)
institución:(a) Laboratory of Medical Investigation, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. (b) Pediatric Rheumatology Unit, Instituto da Criança, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Prevalence of resistance-associated viral variants to the HIV-specific broadly neutralising antibody 10-1074 in a UK bNAb-naïve population.
Prevalence of resistance-associated viral variants to the HIV-specific broadly neutralising antibody 10-1074 in a UK bNAb-naïve population.
Fuente:Frontiers in Immunology
Extracto:
Therefore, we emphasise the importance of screening for
these mutations before initiating 10-1074 therapy, and to consider the
implications of pre-existing resistance when designing prevention strategies.
Claves:10-1074, HIV - human immunodeficiency virus, broadly neutralising antibodies, primary HIV infection (PHI), resistance screening
Cita:Front Immunol 2024; 15 : 1352123.
Autor/es:Zacharopoulou, Panagiota (a) Lee, Ming (b)
institución:(a) Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. (b) Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Mental Health Care Utilization Among Parents of Children With Cancer.
Mental Health Care Utilization Among Parents of Children With Cancer.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: In this cohort study of privately insured parents,
those caring for children with cancer had a higher likelihood of utilizing MH
care than other parents. These findings underline the importance of interventions
toward targeted counseling and support to better meet MH care needs among parents
and caregivers of children with cancer.
Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e244531.
Autor/es:Hu, Xin (a) Grosse, Scott D (b)
institución:(a) Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville. (b) National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.
Conflicto:Conflict of Interest Disclosures: Dr Hu reported receiving grants from the PhRMA Foundation and St Jude Children’s Research Hospital outside the submitted work. Dr Marchak reported receiving grants from the National Institutes of Health, Pfizer, Inc, and Emory University outside the submitted work. Dr Ji reported receiving grants from the National Institutes of Health, Centers for Disease Control and Prevention,...
n, Rally Foundation for Childhood Cancer Research, Leukemia and Lymphoma Society, and Emory University outside the submitted work. No other disclosures were reported.
"There is a strangeness in this disease": A qualitative study of parents' experiences caring for a child diagnosed with COVID-19.
"There is a strangeness in this disease": A qualitative study of parents' experiences caring for a child diagnosed with COVID-19.
Fuente:Plos One
Tipo de trabajo:Guía
Extracto:
Our study highlights that parent experiences
were diverse and multi-faceted, and their experiences evolved and shifted over
the course of the pandemic. Parents would benefit from clear and consistent
evidence-based online information. Understanding the perspectives of parents
caring for a child with COVID-19 is an important step in developing future
resources tailored to meet their unique experiences and information needs.
Cita:PLoS One 2024; 19 (4) : e0300146.
Autor/es:Louie-Poon, Samantha (a) Reid, Kathy (b)
institución:(a) Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada. (b) Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK.
Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK.
Fuente:Nature Communications
Extracto:
Although the potential for misclassification of pre-existing allergic conditions
as incident diseases remains a limitation, ethnic diversity for evidence of
incident allergic diseases in post-COVID-19 condition has been validated by
utilizing multinational and independent population-based cohorts.
Cita:Nat Commun 2024 Apr 2; 15 (1) : 2830.
Autor/es:Oh, Jiyeon (a) Lee, Myeongcheol (b)
institución:(a) Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. (b) Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and neuropsychiatric sequela.
Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and neuropsychiatric sequela.
Fuente:Scientific Reports
Extracto:
Patients with unmet HRSNs experienced worse
long-COVID outcomes compared to those without.
Claves:Covid symptoms, Fatigue, Long covid, PASC, Shortness of breath
Cita:Sci Rep 2024 Apr 2; 14 (1) : 7743.
Autor/es:Eligulashvili, Anna (a) Darrell, Megan (b)
institución:(a) Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. (b) Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Bacterial etiology and antimicrobial resistance pattern of pediatric bloodstream infections: a 5-year experience in an Iranian referral hospital.
Bacterial etiology and antimicrobial resistance pattern of pediatric bloodstream infections: a 5-year experience in an Iranian referral hospital.
Fuente:Bmc Infectious Diseases
Extracto:
Our findings emphasize the need
of clinicians having access to up-to-date bacterial susceptibility data for
routinely prescribed drugs. Continuous monitoring of changes in bacterial
resistance will aid in the establishment of national priorities for local
intervention initiatives in Iran. The increased risk of BSI caused by
antibiotic-resistant organisms, emphasizes the significance of implementing
appropriate antibiotic prescribing regulations and developing innovative
vaccination techniques in Iran.
institución:(a) Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. (b) Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. smamishi@sina.tums.ac.ir.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The plasma kynurenine-to-tryptophan ratio as a biomarker of tuberculosis disease in people living with HIV on antiretroviral therapy: an exploratory nested case-control study.
The plasma kynurenine-to-tryptophan ratio as a biomarker of tuberculosis disease in people living with HIV on antiretroviral therapy: an exploratory nested case-control study.
Fuente:Bmc Infectious Diseases
Extracto:
The plasma K/T ratio
helped identify TB disease and may serve as an adjunctive biomarker for for
monitoring TB treatment in PWH. Validation studies to ascertain these findings
and evaluate the optimum cut-off for diagnosis of TB disease in PWH should be
undertaken in well-designed prospective cohorts. TRIAL REGISTRATION:
ClinicalTrials.gov Identifier: NCT00411983.
Autor/es:Gatechompol, Sivaporn (a) Lutter, René (b)
institución:(a) HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand. sivaporn.k@hivnat.org. (b) Center of Excellence in Tuberculosis, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. sivaporn.k@hivnat.org.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación