New insights into the mechanisms of childhood food allergies.

Fuente:Pediatric Allergy and Immunology Official Publication of The European Society of Pediatric Allergy and Immunology

Extracto: We conclude by providing a perspective on current evidence and directions for future research that will enable new prediction and screening tools and facilitate the development of effective curative strategies.

Claves:childhood, food allergies, immune mechanisms, immunotherapy

Cita:Pediatr Allergy Immunol 2025 Apr; 36 (4) : e70069.

Autor/es:Gubbels, Liam (a)
Saffery, Richard (b)

institución:(a) Molecular Immunity Group, Infection, Immunity and Global Health Theme, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
(b) Molecular Immunity Group, Infection, Immunity and Global Health Theme, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/pai.70069

Expert consensus on imaging diagnosis and analysis of early correction of childhood malocclusion.

Fuente:International Journal of Oral Science

Extracto: This expert consensus is a collaborative effort by multidisciplinary experts in dentistry across the nation based on the current clinical evidence, aiming to provide general guidance on appropriate imaging examination selection, comprehensive and accurate imaging assessment for early orthodontic treatment patients.

Cita:Int J Oral Sci 2025 Apr 1; 17 (1) : 21.

Autor/es:Lin, Zitong (a)
Zhou, Chenchen (b)

institución:(a) Department of Oral Radiology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
(b) Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Conflicto:Competing interests: The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.

Formato:Informe virtual

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.1038/s41368-025-00351-1

Expert consensus on early orthodontic treatment of class III malocclusion.

Fuente:International Journal of Oral Science

Extracto: The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class III malocclusion through early orthodontic treatment.

Cita:Int J Oral Sci 2025 Apr 1; 17 (1) : 20.

Autor/es:Zhou, Xin (a)
Chen, Si (b)

institución:(a) Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
(b) School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.1038/s41368-025-00357-9

ROCK2 Downregulation in Pediatric Medulloblastoma Increases Migration and Predicts the Involvement of SHH Non-canonical Signaling.

Fuente:The Yale Journal of Biology and Medicine

Extracto: Therefore, we propose a model in which the interplay between these pathways may lead to a perturbation of proper cytoskeletal dynamics that underpins cell migration.

Claves:DYPSL3, ROCK2, SHH, medulloblastoma, migration

Cita:Yale J Biol Med 2025 Mar; 98 (1) : 3-19.

Autor/es:Hakime, Rodrigo Guedes (a)
Nagano, Luís Fernando Peinado (b)

institución:(a) Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
(b) Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.59249/QTVT7676

Construction and diagnostic efficacy assessment of the urinary exosomal miRNA-mRNA network in children with IgA vasculitis nephritis.

Fuente:Faseb Journal Official Publication of The Federation of American Societies For Experimental Biology

Extracto: Among them, exosomal hsa-miR-383-5p is highly likely to serve as a novel non-invasive biomarker for assessing the disease status of IgAVN, thereby offering new perspectives on the non-invasive diagnosis and treatment of IgAVN.

Claves:IgA vasculitis, IgA vasculitis nephritis, exosomes, hsa‐miR‐383‐5p, miRNA

Cita:FASEB J 2025 Apr 15; 39 (7) : e70492.

Autor/es:Zhang, Yunfan (a)
Yang, Huanhuan (b)

institución:(a) Department of Pediatrics, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China.
(b) Department of Pediatrics, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1096/fj.202403111R

Managing egg allergy

Fuente:Pediatric Allergy and Immunology Official Publication of The European Society of Pediatric Allergy and Immunology

Tipo de trabajo:Revisión sistemática

Extracto: Factors such as quality of life, including social inclusion and dietary diversity, as well as economic implications are crucial considerations.

Claves:allergen avoidance, dietary advancement therapy, egg allergy management, egg ladder, food allergy

Cita:Pediatr Allergy Immunol 2025 Apr; 36 (4) : e70075.

Autor/es:Gallagher, Aoife (a)
Delgado Mainar, Pamen (b)

institución:(a) Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
(b) Department of Paediatrics, Cork University Hospital, Cork, Ireland.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/pai.70075

Using Multi-Site Research Results to Impact Local Pediatric Pain Evidence-Based Practice: Innovations and Outcomes.

Fuente:Worldviews On Evidence-based Nursing

Tipo de trabajo:Estudio clínico

Extracto: Additional exploration of collaborative strategies between investigators and practice settings in multi-site research is needed for pediatric pain management and beyond.

Claves:evidence‐based practice, information dissemination, magnet, multi‐site research, nursing practice improvement, results sharing

Cita:Worldviews Evid Based Nurs 2025 Apr; 22 (2) : e70011.

Autor/es:Bohr, Nicole L (a)
LaFond, Cynthia M (b)

institución:(a) Department of Nursing Research and Evidence-Based Practice at UChicago Medicine, Chicago, Illinois, USA.
(b) Department of Nursing Research and Evidence-Based Practice at UChicago Medicine, Chicago, Illinois, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1111/wvn.70011

Children's Oral Health Initiative program's impact on First Nations and Inuit children.

Fuente:Canadian Journal of Dental Hygiene Cjdh = Journal Canadien de L'hygiene Dentaire Jchd

Tipo de trabajo:Revisión

Extracto: While no significant decreases in deft scores were identified, the findings suggest that children participating in COHI are receiving needed preventive services such as fluoride varnish and atraumatic restorative therapy.

Claves:Canada, Indigenous, child, dental atraumatic restorative treatment, early childhood caries, government program, preschool, preventive dentistry, public health surveillance

Cita:Can J Dent Hyg 2025 Feb; 59 (1) : 9-17.

Autor/es:Yerex, Katherine (a)
Lee, Juyoung (b)

institución:(a) School of Dental Hygiene, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
(b) Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:

Use of social media by parents as a resource for knowledge on children's oral health

Fuente:Canadian Journal of Dental Hygiene Cjdh = Journal Canadien de L'hygiene Dentaire Jchd

Tipo de trabajo:Revisión sistemática

Extracto: Social media networks play crucial roles in informing, educating, and motivating parents to improve the overall oral health of their children.

Claves:children, internet, oral health, parent education, smartphone, social media

Cita:Can J Dent Hyg 2025 Feb; 59 (1) : 45-58.

Autor/es:Sasikala, Dhandayuthapani (a)
Baghkomeh, Parisa Norouzi (b)

institución:(a) Postgraduate student, Department of Pediatric and Preventive Dentistry, Meenakshi Ammal Dental College and Hospital, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.
(b) Associate professor, Department of Pediatric and Preventive Dentistry, Meenakshi Ammal Dental College and Hospital, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:

Diagnostic contribution of GeneXpert Ultra in pediatric pulmonary tuberculosis.

Fuente:Jornal Brasileiro de Pneumologia Publicacao Oficial Da Sociedade Brasileira de Pneumologia e Tisilogia

Extracto: Ultra significantly contributed to the diagnosis of pediatric PTB, proving to be a promising tool for paucibacillary forms of the disease. However, it should not be used alone. Integrating laboratory tests with clinical evaluation is essential to improving diagnostic accuracy and the management of pediatric TB.

Cita:J Bras Pneumol 2025; 51 (1) : e20240241.

Autor/es:Battaglia, Claudia Stella Pereira (a)
Parente, Ana Alice Amaral Ibiapina (b)

institución:(a) Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ), Brasil.
(b) Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ), Brasil.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Brasil

Sitio web:http://dx.doi.org/10.36416/1806-3756/e20240241

Addressing model discrepancy in a clinical model of the oxygen dissociation curve.

Fuente:Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences

Extracto: We compare and discuss the effectiveness of these approaches in handling model discrepancy using clinical data from the ICU and the Siggaard-Andersen oxygen status algorithm.This article is part of the theme issue 'Uncertainty quantification for healthcare and biological systems (Part 2)'.

Claves:Gaussian processes, model discrepancy, neural networks, scientific machine learning, symbolic regression

Cita:Philos Trans A Math Phys Eng Sci 2025 Apr 2; 383 (2293) : 20240213.

Autor/es:Grigorian, Gevik (a)
Volodina, Victoria (b)

institución:(a) Department of Mechanical Engineering, University College London, London, UK.
(b) Department of Mathematics and Statistics, University of Exeter, Exeter, UK.

Conflicto:We declare we have no competing interests.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1098/rsta.2024.0213

[Formulation Design that Contributes to the Development of Pediatric-friendly Drugs].

Fuente:Yakugaku Zasshi Journal of The Pharmaceutical Society of Japan

Extracto: MTs did not differ significantly from FGs and LFs in acceptability for infants, but this new endpoint is useful for evaluating oral pediatric formulations.

Claves:acceptability, composite endpoint, mini-tablet, palatability, pediatric formulation, swallowability

Cita:Yakugaku Zasshi 2025; 145 (4) : 289-297.

Autor/es:acceptability, composite endpoint, mini-tablet, palatability, pediatric formulation, swallowability

institución:acceptability, composite endpoint, mini-tablet, palatability, pediatric formulation, swallowability

Formato:Informe impreso

Idioma:jpn

País de fuente:Japón

Sitio web:http://dx.doi.org/10.1248/yakushi.24-00171-3

Expert consensus on orthodontic treatment of patients with periodontal disease.

Fuente:International Journal of Oral Science

Extracto: This expert consensus, informed by the latest clinical research and practical experience, addresses clinical considerations for orthodontic treatment of periodontal patients, delineating indications, objectives, procedures, and principles with the aim of providing clear and practical guidance for clinical practitioners.

Cita:Int J Oral Sci 2025 Apr 3; 17 (1) : 27.

Autor/es:Zhong, Wenjie (a)
Zhou, Chenchen (b)

institución:(a) College of Stomatology, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, China.
(b) State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.1038/s41368-025-00356-w

Demand for cardiopulmonary resuscitation and bleeding control skills training in an urban region

Demand for cardiopulmonary resuscitation and bleeding control skills training in an urban region

Fuente:Frontiers in Public Health

Tipo de trabajo:Revisión

Extracto: Further, utilizing community liaisons, such as community health workers, was critical to its success.

Claves:bystander CPR, community engagement, community health worker, health equity, pedagogy, population health

Cita:Front Public Health 2025; 13 : 1339215.

Autor/es:Hoops, Katherine (a)
Bedner, Ashley (b)

institución:(a) Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
(b) Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2025.1339215

Frontiers in subclinical atherosclerosis and the latest in early life preventive cardiology.

Frontiers in subclinical atherosclerosis and the latest in early life preventive cardiology.

Fuente:Singapore Medical Journal

Extracto: Emphasising early education on cardiovascular health can fundamentally shift the trajectory of cardiovascular disease prevention and optimise long-term health outcomes.

Cita:Singapore Med J 2025 Mar 1; 66 (3) : 141-146.

Autor/es:Dalakoti, Mayank (a)
Chen, Ching Kit (b)

institución:(a) Cardiovascular Metabolic Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
(b) Department of Cardiology, National University Heart Centre, National University Health System, Singapore.

Formato:Informe impreso

Idioma:Inglés

País de fuente:India

Sitio web:http://dx.doi.org/10.4103/singaporemedj.SMJ-2024-169

Using Wear Time for the Analysis of Consumer-Grade Wearables' Data: Case Study Using Fitbit Data.

Using Wear Time for the Analysis of Consumer-Grade Wearables' Data: Case Study Using Fitbit Data.

Fuente:Jmir Mhealth and Uhealth

Extracto: We leveraged datasets from diverse populations to demonstrate the direct relationship between parameter estimates from consumer-grade wearable devices and participants' wear time. Our findings highlighted the importance of a thorough analysis of wear time when processing data from consumer-grade wearables to ensure the relevance and reliability of the associated findings.

Claves:Fitbit, behavior, caregiver, dataset, engagement, mobile health, physical activity, reliability, smartwatch, students, users, walking, wear time, wearable devices, wearables

Cita:JMIR Mhealth Uhealth 2025 Mar 21; 13 : e46149.

Autor/es:Baroudi, Loubna (a)
Zernicke, Ronald Fredrick (b)

institución:(a) Department of Mechanical Engineering, University of Michigan-Ann Arbor, 2505 Hayward St, Ann Arbor, MI, 48109, United States, 1 7342626353.
(b) Department of Orthopedic Surgery, University of Michigan-Ann Arbor, Ann Arbor, MI, United States.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.2196/46149

External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis.

External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis.

Fuente:Jama Network Open

Extracto: AND RELEVANCE: In this multicenter diagnostic study of children hospitalized with suspected sepsis, the Phoenix Sepsis Score and sepsis criteria had similar performance to the original derivation and validation cohorts. The small proportion of children meeting Phoenix sepsis criteria, missingness of data, timing of application, and lack of sensitivity for in-hospital mortality limit the clinical utility of the criteria.

Cita:JAMA Netw Open 2025 Mar 3; 8 (3) : e251412.

Autor/es:Long, Elliot (a)
Borland, Meredith L (b)

institución:(a) Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.
(b) Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.

Conflicto:Conflict of Interest Disclosures: Dr Dalziel reported receiving grants from Cure Kids New Zealand during the conduct of the study. Dr Balamuth reported receiving grants from the National Institutes of Health and Children’s Hospital of Philadelphia for connected clinical trial PROMPT BOLUS during the conduct of the study. Dr Kuppermann reported receiving grants from the National Institutes of Health and... nd the Health Resources and Services Administration outside the submitted work. Dr Babl reported grants from The National Health and Medical Research Foundation (NHMRC) and the Medical Research Futures Fund (MRFF) during the conduct of the study and an NHMRC leadership grant to the Royal Children Hospital Foundation outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2025.1412

State Earned Income Tax Credits and Firearm Suicides.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: In this cohort study, the presence and generosity of state refundable EITCs were associated with a decrease in firearm suicide rates, supporting the growing body of literature highlighting the importance of antipoverty policies for reducing firearm suicide.

Cita:JAMA Netw Open 2025 Mar 3; 8 (3) : e251398.

Autor/es:Asa, Nicole (a)
Ellyson, Alice (b)

institución:(a) Department of Epidemiology, School of Public Health, University of Washington, Seattle.
(b) Firearm Injury and Policy Research Program, School of Medicine, University of Washington, Seattle.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2025.1398

Target weight at discharge for children receiving their first inpatient treatment for an eating disorder.

Target weight at discharge for children receiving their first inpatient treatment for an eating disorder.

Fuente:Eating and Weight Disorders Ewd

Tipo de trabajo:Consenso

Extracto: Discharging pediatric patients at a higher weight is associated with improved weight recovery and a reduced risk of rehospitalization. A target discharge weight of 86.4%IBW may serve as an effective criterion for children with EDs. LEVEL OF EVIDENCE: III, case-control analytic studies.

Claves:Adolescent, Child, Eating disorder, Feeding disorder, Follow-up study, Inpatient, Weight gain

Cita:Eat Weight Disord 2025 Mar 21; 30 (1) : 29.

Autor/es:Kurata, Kazumi (a)
Inagawa, Yuta (b)

institución:(a) Department of Psychiatry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi, 329-0498, Japan.
(b) Department of Psychiatry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi, 329-0498, Japan. d07sm011@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s40519-025-01736-1

Large Language Model-Based Assessment of Clinical Reasoning Documentation in the Electronic Health Record Across Two Institutions: Development and Validation Study.

Large Language Model-Based Assessment of Clinical Reasoning Documentation in the Electronic Health Record Across Two Institutions: Development and Validation Study.

Fuente:Journal of Medical Internet Research

Extracto: This is the first multi-institutional study to apply LLMs for assessing CR documentation in the electronic health record. Such tools can enhance feedback on CR. Lessons learned by implementing these models at distinct institutions support the generalizability of this approach.

Claves:artificial intelligence, assessment, clinical reasoning, documentation, electronic health record, feedback, large language models

Cita:J Med Internet Res 2025 Mar 21; 27 : e67967.

Autor/es:Schaye, Verity (a)
DiTullio, David (b)

institución:(a) Department of Medicine, NYU Grossman School of Medicine, New York, NY, United States.
(b) Institute for Innovations in Medical Education, NYU Grossman School of Medicine, New York, NY, United States.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.2196/67967