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Sex-specific spirometry effects of adult COPD polygenic score in children with asthma.
Sex-specific spirometry effects of adult COPD polygenic score in children with asthma.
Fuente:Scientific Reports
Extracto:
The findings underscore the
need to include diverse populations in genomic studies to improve the
generalizability of PS for COPD prevention.
Claves:Ancestry, COPD, Lung function, Pediatric, Polygenic score, Sex
Cita:Sci Rep 2025 Apr 2; 15 (1) : 11258.
Autor/es:Kelchtermans, Jelte (a) Collaco, Joseph M (b)
institución:(a) Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA, 19104, USA. kelchtermj@chop.edu. (b) Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kelchtermj@chop.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical breast cancer screening uptake and associated factors among reproductive age women in Kenya: further analysis of Kenyan Demographic and Health Survey 2022.
Clinical breast cancer screening uptake and associated factors among reproductive age women in Kenya: further analysis of Kenyan Demographic and Health Survey 2022.
Fuente:Plos One
Extracto:
In this study, the prevalence of CBCSU
among reproductive-age women in Kenya was found to be low. Besides, factors such
as age, educational status, wealth index, family planning utilization, and
community media exposure were identified as significant contributors to screening
uptake. Therefore, policymakers and stakeholders should design interventions that
address factors contributing to low breast cancer screening uptake, particularly
targeting women in areas with limited media exposure, to increase the uptake of
clinical breast cancer screening.
institución:(a) Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. (b) Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Fetal umbilical vein thrombosis associated with fetal bartter syndrome
Fetal umbilical vein thrombosis associated with fetal bartter syndrome
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Revisión
Extracto:
This case highlights a suspected instance of umbilical vein
thrombosis and polyhydramnios potentially linked to fetal Bartter syndrome.
Currently, the causes of umbilical vein thrombosis primarily focus on
abnormalities in umbilical cord structure or mechanical injury to the cord, with
few cases involving fetal genetic conditions. The purpose of this report is to
enhance medical professionals' understanding of Bartter syndrome and to consider
it as a possible cause of fetal umbilical vein thrombosis and polyhydramnios.
Further research should explore the link between fetal Bartter syndrome,
umbilical vein thrombosis, and polyhydramnios. Additionally, strengthening case
collection and analysis will help accumulate experience, optimize management
strategies, and improve maternal and fetal outcomes.
Cita:BMC Pregnancy Childbirth 2025 Mar 29; 25 (1) : 371.
Autor/es:Zhao, Jinglin (a) Xing, Aiyun (b)
institución:(a) Department of Ultrasound Medicine, West China Hospital of Sichuan University, Sichuan Province, Chengdu, 610041, China. (b) Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Diagnosing diagnostic error of endometriosis: a secondary analysis of patient experiences from a mixed-methods survey.
Diagnosing diagnostic error of endometriosis: a secondary analysis of patient experiences from a mixed-methods survey.
Fuente:Bmj Open Quality
Extracto:
Examining a series of patient-described diagnostic errors
reported by patients with surgically confirmed endometriosis using three
validated taxonomies demonstrates numerous areas for improvement. These findings
can help patients, clinicians and healthcare organisations better anticipate
errors in endometriosis diagnosis and design and implement education efforts and
safety to prevent or mitigate such errors.
Claves:Communication, Diagnostic errors, Health services research, Obstetrics and gynecology, Patient-centred care
Cita:BMJ Open Qual 2025 Mar 31; 14 (1)
Autor/es:Bontempo, Allyson C (a) Schiff, Gordon D (b)
institución:(a) Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA allyson.bontempo@rutgers.edu. (b) Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The effect of incubator humidity on morbidity and mortality in preterm infants
The effect of incubator humidity on morbidity and mortality in preterm infants
Fuente:Bmc Pediatrics
Tipo de trabajo:Revisión sistemática
Extracto:
This study found
that high humidity levels had a significant impact on the incidence of infection.
Current evidence is limited by signifcant heterogeneity across studies, lack of
data related to regarding the effects of factors such as humidity duration and
humidity adjustment schemes on the outcomes.
institución:(a) Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Afffliated Hospital, Guangzhou Medical University, Guangzhou, China. (b) Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prediction of pulmonary artery sling in children using echocardiography: scoring based on pulmonary artery bifurcation and pulmonary valve ring distance.
Prediction of pulmonary artery sling in children using echocardiography: scoring based on pulmonary artery bifurcation and pulmonary valve ring distance.
Fuente:Cardiovascular Ultrasound
Extracto:
The pivotal element in
echocardiography diagnosis of PAS is the identification of the spatial
relationship between the left pulmonary artery (LPA) and the trachea. The use of
quantitative indices such as DBP and DBP/BSA for adjunctive diagnosis can
positively impact the early detection of PAS.
institución:(a) Department of Medical Ultrasonics, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, China. (b) Department of Cardiac Surgery, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fujian Medical University, Fuzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Development of the Japanese version of the perceived time poverty scale.
Development of the Japanese version of the perceived time poverty scale.
Fuente:Plos One
Extracto:
The
Japanese version of the Perceived Time Poverty Scale is a reliable tool with a
certain degree of validity for assessing time poverty in Japan. This scale
enables individuals and households to recognize time poverty as a modern form of
poverty. Furthermore, businesses and local governments can utilize it as an
indicator in practical settings, such as improving work environments,
implementing childcare support programs, and promoting community health. Future
longitudinal studies are needed to further validate the scale, including
addressing issues related to model fit.
Cita:PLoS One 2025; 20 (4) : e0320807.
Autor/es:Miura, Takeshi (a) Hara, Koji (b)
institución:(a) Department of Health Data Science, Yokohama City University, Yokohama, Kanagawa, Japan. (b) Nursing Course, School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Paediatrics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Sungang West Road No. 3002, Shenzhen, 518035, Guangdong Province, China. (b) Department of Paediatrics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Sungang West Road No. 3002, Shenzhen, 518035, Guangdong Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
School-age outcomes among IVF and ICSI-conceived children: a causal inference analysis using linked population-wide data.
School-age outcomes among IVF and ICSI-conceived children: a causal inference analysis using linked population-wide data.
Fuente:Bmc Medicine
Tipo de trabajo:Estudio clínico
Extracto:
Our findings suggest that the use of ICSI in IVF cycles without
severe male factor infertility does not increase the risk of early childhood
developmental vulnerability among children in their first year of school. These
findings provide important reassurance for current and prospective parents and
clinicians alike.
Autor/es:Kennedy, Amber L (a) Hiscock, Richard J (b)
institución:(a) Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Parkville, Melbourne, 3052, Australia. amber.kennedy@unimelb.edu.au. (b) Mercy Perinatal, Mercy Hospital for Women, Heidelberg, VIC, Australia. amber.kennedy@unimelb.edu.au.
Conflicto:Declarations. Ethics approval and consent to participate: Each data custodian provided contractual approval for data access and linkage. Given the retrospective and deidentified nature of this study, individual participant informed consent was not required. Ethical approval for the project was obtained from Mercy, Monash Health and Melbourne IVF Health Human Research Ethics Committees. Consent for publication: Not applicable. Competing interests:...
All authors have completed the ICMJE uniform disclosure form ( http://www.icmje.org/disclosure-of-interest/ ). Most authors have declared that no competing interests exist. A.L.K has received various education sponsorship and honoraria from Merck PTY LTD and Organon Pharma PTY LTD unrelated to this project. B.V has a paid role as a member of the Therapeutic Good Administration. T.O, B.V, F.A and K.S own shares in respective IVF companies (Newlife IVF, Monash IVF, Virtus Health and Melbourne IVF). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Dynamics of T cell subpopulations and plasma cytokines during the first year of antineoplastic therapy in patients with breast cancer: the BEGYN-1 study.
Dynamics of T cell subpopulations and plasma cytokines during the first year of antineoplastic therapy in patients with breast cancer: the BEGYN-1 study.
Fuente:Breast Cancer Research Bcr
Extracto:
We conclude that in breast cancer patients, chemotherapy is associated with a
transition from a Th1 immune response towards Th2 and an increase in cytotoxic T
cells, whereas in patients without chemotherapy, these alterations were less
pronounced. Future studies should clarify whether patterns of T cell subsets or
plasma cytokines can be used as biomarkers to monitor or even improve therapeutic
interventions.
Claves:Biomarkers, Breast cancer, Chemotherapy, Cytokines, Endocrine therapy, T cells
Cita:Breast Cancer Res 2025 Apr 1; 27 (1) : 50.
Autor/es:Kaiser, Elisabeth (a) Weber, Regine (b)
institución:(a) Department of General Pediatrics and Neonatology, Saarland University, Campus Homburg, 66421, Homburg/Saar, Germany. (b) Department of General Pediatrics and Neonatology, Saarland University, Campus Homburg, 66421, Homburg/Saar, Germany. regine.stutz@uni-saarland.de.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Are medical associations' paid parental leave recommendations instituted for United States medical school faculty?
Are medical associations' paid parental leave recommendations instituted for United States medical school faculty?
Fuente:Medical Education Online
Extracto:
This suggests that most parental leave policies offered to academic medicine
faculty are misaligned with medical associations' recommendations.
institución:(a) Tufts University School of Medicine, Boston, MA, USA. (b) Department of Medical Education, Tufts University School of Medicine, Boston, MA, USA.
Interpretable machine learning model for early prediction of disseminated intravascular coagulation in critically ill children.
Interpretable machine learning model for early prediction of disseminated intravascular coagulation in critically ill children.
Fuente:Scientific Reports
Extracto:
Machine learning models can be a reliable tool for predicting DIC in
critically ill children, which will facilitate timely intervention, thereby
reducing the burden of DIC on patients in the pediatric intensive care unit
(PICU).
Claves:Critically ill children, Disseminated intravascular coagulation, Machine learning, Model interpretation
Cita:Sci Rep 2025 Apr 2; 15 (1) : 11217.
Autor/es:Zhou, Jintuo (a) Xie, Yongjin (b)
institución:(a) Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, #18 Daoshan Road, Fuzhou, China. (b) Department of Obstetrics and Gynecology, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, #18 Daoshan Road, Fuzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Colorectal cancer at the anastomotic site following childhood surgery for hirschsprung disease
Colorectal cancer at the anastomotic site following childhood surgery for hirschsprung disease
Fuente:World Journal of Surgical Oncology
Tipo de trabajo:Caso clínico
Extracto:
This case
highlights the need for awareness of potential colorectal cancer development in
patients with a history of Hirschsprung disease and emphasizes the importance of
individualized management and close surveillance strategies.
Claves:Case report, Duhamel procedure, Hirschsprung disease, Intersphincteric resection, Rectal cancer
institución:(a) Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany. Matthias.mehdorn@medizin.uni-leipzig.de. (b) Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.
Conflicto:Declarations. Ethics approval and consent to participate: Written informed consent was given by the patient for the publication of this case report. The consent form is available from the corresponding author upon reasonable request. Competing interests: None of the authors has any conflict of interest to declare in relation to the presented manuscript.
Safety analysis of self-administered enzyme replacement therapy using data from the Fabry Outcome and Gaucher Outcome Surveys.
Safety analysis of self-administered enzyme replacement therapy using data from the Fabry Outcome and Gaucher Outcome Surveys.
Fuente:Orphanet Journal of Rare Diseases
Extracto:
These findings suggest that
self-administration of agalsidase alfa or velaglucerase alfa infusions are not
associated with additional safety risks compared with HCP-supported infusions and
are a suitable option for qualifying patients. Further research is warranted to
support these findings and to explore further the long-term safety and efficacy
of ERT self-administration. FOS trial registration: ClinicalTrials.gov,
NCT03289065. Registered 01 April 2001,
https://clinicaltrials.gov/study/NCT03289065 . GOS trial registration:
ClinicalTrials.gov, NCT03291223. Registered 27 July 2010, https://classic.
CLINICALTRIALS: gov/ct2/show/NCT03291223 .
Autor/es:Revel-Vilk, Shoshana (a) Ramaswami, Uma (b)
institución:(a) Gaucher Unit and Pediatric Hematology/Oncology Unit, The Eisenberg R&D Authority, Shaare Zedek Medical Center, Jerusalem, Israel. (b) Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Conflicto:Declarations. Ethics approval and consent to participate: FOS and GOS registries have been approved by the ethics institutional review boards of participating centers and are conducted in compliance with relevant global and local regulations and best practices, Good Pharmacoepidemiological Practice, Good Research for Comparative Effectiveness principles, and the relevant principles of the International Conference on Harmonisation Good Clinical Practice guidelines...
(ICH E6), as appropriate for an observational registry. All participants provided written informed consent. Consent for publication: Not applicable. Competing interests: SRV received grant/research support, honoraria, and advisory fees from Pfizer, Sanofi/Genzyme and Takeda. UR received honoraria for lectures and advisory boards from Amicus, Sanofi and Takeda; research grants from Amicus, Intrabio and Takeda. GPM received honoraria as a speaker and/or consultancy from Amicus, Chiesi, Lucane, and Takeda and unrestricted grants for research of Rare Diseases at VHIR from Sanofi and Takeda. DH received honoraria for speaking and advisory boards from Amicus, Chiesi, Freeline, Idorsia, Sangamo, Sanofi and Takeda. KN reports honoraria from Amicus Therapeutics, Sanofi Genzyme, and Takeda; and is a member of the FOS Steering Committee. RR reports honoraria, speaker fees, and consulting fees from Amicus Therapeutics, CSL Behring, Gador, Sanofi Genzyme, Novartis, and Takeda; and is a member of the FOS Steering Committee. RG received research grants, investigator fees, speaker/consultancy honoraria, and travel support to attend scientific meetings from Allievex, Amicus, Avrobio, Asafaros, BioMarin, Chiesi, Cyclo, DASA, Idorsia, Inventiva, Janssen, JCR, Lysogene, Novartis, Paradigm, PassageBio, Pfizer, Protalix, PTC, RegenxBio, Sanofi, Sigilon, Sobi,Takeda and Ultragenyx. OGA has received grant support from 4DMT, Chiesi, Idorsia, Protalix, Sangamo, and Sanofi for clinical research trials and from Sanofi and Takeda for other investigator-initiated studies; consulting fees from Chiesi, Sanofi, Takeda, and Uniqure; honoraria for speaker bureaus from Sanofi and Takeda and participates on the Advisory Board on Fabry Disease for Chiese and Sanofi. MI received support for the SZMC Gaucher Unit from Sanofi/Genzyme for participation in the ICGG Registry, from Takeda for the GOS Registry, and Pfizer for TALIAS; the Unit also receives research grants from Centogene, Pfizer, Sanofi/Genzyme and Takeda. AG was an employee of Takeda and stockholder in Takeda at the time of study start. MS has received honoraria and travel support from Alexion, Bi-938 oMarin, CHIESI, Orchard, Regenexbio, Sanofi, Takeda, and Ultragenyx. JB is an employee of Takeda and holds stock options in Takeda.
New insights into the cultivability of human milk bacteria from ingestion to digestion and implications for their Immunomodulatory properties.
New insights into the cultivability of human milk bacteria from ingestion to digestion and implications for their Immunomodulatory properties.
Fuente:Scientific Reports
Extracto:
These
results highlight the potential of HM bacteria to survive during the infant
gastrointestinal digestion and interact with the intestinal epithelium and immune
system, as well as the importance of considering the digestion process when
evaluating host-bacteria interactions.
Claves:Bacterial cultivability, Bacterial viability, Breast milk microbiota, Gastrointestinal digestion, Immunomodulatory properties, In vitro digestion
Cita:Sci Rep 2025 Mar 31; 15 (1) : 10985.
Autor/es:Le Bras, Charles (a) Mouchard, Alizé (b)
institución:(a) STLO, INRAE, Institut Agro Rennes Angers, Rennes, France. (b) Institut NuMeCan, INRAE, INSERM, Université de Rennes, Saint Gilles, France.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prevalence, associated factors, and clinical outcomes of Helicobacter pylori infection in pediatric populations in a war-torn urban environment in Eastern Democratic Republic of Congo: a mixed methods study.
Prevalence, associated factors, and clinical outcomes of Helicobacter pylori infection in pediatric populations in a war-torn urban environment in Eastern Democratic Republic of Congo: a mixed methods study.
Fuente:Bmc Pediatrics
Extracto:
Children with occult blood in stool and
microcytic anemia should be tested for H. pylori using stool antigen tests.
Treatment with clarithromycin should be guided by local antibiotic resistance
data. Hygiene education, including safe water practices and managing pet contact,
is crucial due to their association with H. pylori infection.
Autor/es:Tibasima, Emmanuel Busha (a) Kumbakulu, Patrick Kumbowi (b)
institución:(a) Department of Paediatrics and Child Health, Université Libre Des Pays Des Grands Lacs, Goma, Democratic Republic of Congo. (b) Department Of Pediatric and Child Health Samaritan Doctor'S Pediatric Centre, Goma, Democratic Republic of Congo.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Methylmalonic acidemia with recurrent hemophagocytic lymphohistiocytosis
Methylmalonic acidemia with recurrent hemophagocytic lymphohistiocytosis
Fuente:Bmc Pediatrics
Tipo de trabajo:Revisión
Extracto:
HLH is a rare and underrecognized
hematologic emergency in methylmalonic acidemia, and its early diagnosis and
treatment are critical. Serum ferritin may be a useful clinical biomarker in the
diagnosis of HLH-associated attacks in methylmalonic acidemia.
The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease.
The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease.
Fuente:Biology Direct
Extracto:
The PT-dependent ER stress observed in the IECs of CD patients
results from the excessive release of calcium from the ER. Importantly,
inhibition of this signaling pathway abrogates ER stress, which in turn
attenuates downstream signs of CD, such as TG2 expression and gut permeability
dysregulation, as well as inhibits inflammation.
Claves:CD, CXCR3, IEC, IP3R, PKC, UPR
Cita:Biol Direct 2025 Mar 31; 20 (1) : 39.
Autor/es:Monzani, Romina (a) Gagliardi, Mara (b)
institución:(a) Department of Health Sciences, School of Medicine, Center for Translational Research on Autoimmune and Allergic Disease (CAAD), University of Piemonte Orientale, Novara, Italy. (b) Department of Health Sciences, School of Medicine, Center for Translational Research on Autoimmune and Allergic Disease (CAAD), University of Piemonte Orientale, Novara, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The Inflammatory Bowel Disease Knowledge Inventory Device 2 (IBD-KID2) is an effective tool for measuring disease-specific knowledge in Chinese patients.
The Inflammatory Bowel Disease Knowledge Inventory Device 2 (IBD-KID2) is an effective tool for measuring disease-specific knowledge in Chinese patients.
Fuente:Plos One
Tipo de trabajo:Revisión
Extracto:
The Chinese version of the IBD-KID2 demonstrated satisfactory reliability and
validity, making it a robust instrument for evaluating disease-specific knowledge
in individuals with IBD.
Cita:PLoS One 2025; 20 (4) : e0321036.
Autor/es:Huang, HaiQun (a) Li, Ping (b)
institución:(a) Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China. (b) Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Understanding global mobility of dietetic talents: a survey study of overseas-educated dietetic returnees in China.
Understanding global mobility of dietetic talents: a survey study of overseas-educated dietetic returnees in China.
Fuente:Globalization and Health
Extracto:
Returnees
have diverse career pathways. Post-return job satisfaction, however, was
significantly predicted only by salary level, emphasizing the critical role of
compensation and economic viability in sustaining careers in the dietetic field.
Our findings suggest that while returnees were primarily motivated by personal
and cultural factors, they faced significant re-entry challenges that warrant
attention from educators and policymakers. Future research should explore the
global mobility of the dietetic profession and its potential to contribute to
'brain gain' in China's healthcare sector.
Claves:Brain circulation, Brain gain, China, Dietetic returnees, Global mobility, Healthcare workforce, International education, Job satisfaction, Registered dietitian
Cita:Global Health 2025 Apr 1; 21 (1) : 15.
Autor/es:Zhang, Yajie (a) Zheng, Luyue (b)
institución:(a) Department of Clinical Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, PR China. jacy9009@hotmail.com. (b) Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, NO.1665, Kongjiang Road, Shanghai, 200092, PR China. jacy9009@hotmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
