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A dynamic transmission model for assessing the impact of pneumococcal vaccination in the United States.
A dynamic transmission model for assessing the impact of pneumococcal vaccination in the United States.
Fuente:Plos One
Extracto:
Projections revealed that
PCV15 would reduce IPD incidence by 6.04% (range: 6.01% to 6.06%) over 10 years
when compared to PCV13.
Cita:PLoS One 2025; 20 (4) : e0305892.
Autor/es:Malik, Tufail M (a) Bakker, Kevin M (b)
institución:(a) Merck & Co., Inc., Rahway, New Jersey, United States of America. (b) Merck & Co., Inc., Rahway, New Jersey, United States of America.
Conflicto:The authors have read the journal’s policy and have the following competing interests: TMM, KMB, RJO, OS, and EHE are full-time employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA and may hold stock or stock options in Merck & Co., Inc., Rahway, NJ, USA. GM and RBN are consultants whose institution...
on (Wolfram Research, Inc., Champaign IL, USA) is paid by Merck Sharp & Dohme. RBN may hold stock or stock options in Merck & Co., Inc., Rahway, NJ, USA. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.
A realistic FastQ-based framework FastQDesign for ScRNA-seq study design issues.
A realistic FastQ-based framework FastQDesign for ScRNA-seq study design issues.
Fuente:Communications Biology
Extracto:
A high-efficiency
software suite is available at https://github.com/yuw444/FastQDesign .
Cita:Commun Biol 2025 Apr 2; 8 (1) : 547.
Autor/es:Wang, Yu (a) Chen, Yi-Guang (b)
institución:(a) Division of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, USA. (b) Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cryptococcus albidus fungemia and probable meningitis in very preterm newborn
Cryptococcus albidus fungemia and probable meningitis in very preterm newborn
Fuente:Bmc Pediatrics
Tipo de trabajo:Revisión
Extracto:
This case report underscores the importance of early diagnosis and
appropriate antifungal treatment for managing rare fungal infections in
vulnerable populations, such as preterm infants. Moreover, it highlights the need
for improved diagnostic platforms and comprehensive management protocols for rare
pathogens in neonatal settings.
Claves:Cryptococcus albidus, Case report, Fungemia, Liposomal amphoterici, Premature
Cita:BMC Pediatr 2025 Apr 2; 25 (1) : 269.
Autor/es:Aljehani, Sameera Mohmmed (a) Zaidan, Tasneem Ibraheem A (b)
institución:(a) Department of Pediatric-Infectious Diseases, King Abdulaziz Hospital, Almahjar Street, Jeddah, 22425, Saudi Arabia. dr.s.m@hotmail.com. (b) Department of Pediatric-Infectious Diseases, King Abdulaziz Hospital, Almahjar Street, Jeddah, 22425, Saudi Arabia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Depressive symptoms and its determinants among people living with HIV in Africa
Depressive symptoms and its determinants among people living with HIV in Africa
Fuente:Bmc Psychiatry
Tipo de trabajo:Revisión sistemática
Extracto:
This review concluded
that one-third of people living with HIV in Africa suffered from depressive
symptoms. Additionally, individuals experiencing stigma, poor social support, a
CD4 count < 200, and comorbid chronic illnesses, as well as females suffered more
from depressive symptoms. Therefore, mental health assessments should address
these factors. PROSPERO REGISTRATION NUMBER: CRD42024516528.
Claves:Africa, Associated factors, Depressive symptoms, People living with HIV, Pooled prevalence
institución:(a) Department of Psychiatry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. gebrietadesse21@gmail.com. (b) Department of Psychiatry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Unravelling a pediatric enigma: coexisting retroesophageal right subclavian artery and congenital colonic stenosis masquerading as cow's milk protein allergy and ileus in a neonate.
Unravelling a pediatric enigma: coexisting retroesophageal right subclavian artery and congenital colonic stenosis masquerading as cow's milk protein allergy and ileus in a neonate.
Fuente:Bmc Pediatrics
Extracto:
This case highlights the diagnostic complexities of RRSA and
CCS resulting in double gut obstruction and masquerading as non-IgE-mediated
cow's milk protein allergy and sepsis-induced ileus. Awareness of these rare
coexisting congenital anomalies can aid in early recognition, prevent
misdiagnosis, enable timely management and improve outcomes for affected
pediatric patients.
Claves:Abdominal distension, Congenital colonic stenosis, Cow's milk protein allergy, Gut obstruction, Ileus, Misdiagnosis, Neonatal vomiting, Reflux, Retroesophageal right subclavian artery, Sepsis
institución:(a) Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand. (b) Chulabhorn International College of Medicine (CICM), Thammasat University, Pathumthani, 12120, Thailand.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Outcomes of neonatal hyperbilirubinemia and associated factors at a tertiary hospital in Ghana.
Outcomes of neonatal hyperbilirubinemia and associated factors at a tertiary hospital in Ghana.
Fuente:Bmc Pediatrics
Tipo de trabajo:Estudio de cohortes
Extracto:
The incidence
of hyperbilirubinemia among neonates admitted to the Mother Baby Unit at KATH is
high and gestational ages between 35 and 37 weeks, abnormal posture and older age
at presentation were identified to be significantly associated with mortality.
Autor/es:Brobby, Naana Ayiwa Wireko (a) Nguah, Samuel Blay (b)
institución:(a) Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, P.O. Box 1098, Kumasi, Ghana. mayiwah@yahoo.com. (b) Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana. mayiwah@yahoo.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Unravelling the link between alexithymia and psychological distress in nurses: a multi-hospital cross-sectional study exploring the mediating roles of workplace conflict and emotional exhaustion.
Unravelling the link between alexithymia and psychological distress in nurses: a multi-hospital cross-sectional study exploring the mediating roles of workplace conflict and emotional exhaustion.
Fuente:Bmc Psychiatry
Extracto:
This study suggests that alexithymia not only directly affects psychological
distress but also exerts chain mediation effects through workplace conflict and
emotional exhaustion. The findings unravel the complex mechanisms underlying the
alexithymia-psychological distress link, providing valuable insights to guide
efforts in safeguarding nurses' mental health. By addressing alexithymia and
cultivating a supportive organizational environment, managers can facilitate the
build-up of emotional resources, ultimately enhancing the psychological
well-being of nurses.
institución:(a) Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. (b) Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Initial experience of thulium fiber laser in retrograde intrarenal surgery for ureteral and renal stones in Japan: surgical outcomes and safety assessment compared with holmium: yttrium-aluminum-garnet with MOSES technology.
Initial experience of thulium fiber laser in retrograde intrarenal surgery for ureteral and renal stones in Japan: surgical outcomes and safety assessment compared with holmium: yttrium-aluminum-garnet with MOSES technology.
Fuente:Bmc Urology
Extracto:
Our study showed that RIRS with TFL had similar results and
no difference in complications compared to RIRS with Ho: YAG laser with MOSES
technology. The TFL had a significantly shorter basketing time than the Ho: YAG
laser with MOSES technology. Furthermore, future research is needed to determine
suitable laser settings for the TFL.
institución:(a) Department of Urology, Hachinohe Heiwa Hospital, Hachinohe, Japan. (b) Department of Urology, Yotsuya Medical Cube, Tokyo, Japan. g-anan@mcube.jp.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Children's palliative care and public health: position statement.
Children's palliative care and public health: position statement.
Fuente:Bmc Palliative Care
Extracto:
The public health approach to children's palliative
care is radical, it is transformational, and means changing how we do things in
order to improve the lives of children with palliative care needs and their
families around the world.
Claves:Children, Co-production, Community, Global, Paediatrics, Palliative care, Public health
Cita:BMC Palliat Care 2025 Apr 2; 24 (1) : 89.
Autor/es:Downing, Julia (a) Randall, Duncan (b)
institución:(a) Makerere/ Mulago Palliative Care Unit, Palliative care Education and Research Consortium, Kampala, Uganda. julia.downing@icpcn.org. (b) International Children's Palliative Care Network, Bristol, UK. julia.downing@icpcn.org.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
First pediatric case of spermatic cord fibrolipoma
First pediatric case of spermatic cord fibrolipoma
Fuente:Bmc Urology
Tipo de trabajo:Revisión
Extracto:
To our knowledge, this
pediatric patient represents the first reported case of spermatic cord
fibrolipoma. Although benign, fibrolipomas can present with acute scrotal
symptoms and mimic more urgent conditions, such as torsion of an accessory
testis. The possibility of fibrolipoma, while rare, should be considered in the
differential diagnosis of a paratesticular mass to prevent misdiagnosis and
potential testicular compromise. Optimal outcomes depend on early detection,
accurate imaging, and prompt surgical intervention.
Claves:Fibrolipoma, Paratesticular mass excision, Rare tumors
Cita:BMC Urol 2025 Apr 2; 25 (1) : 69.
Autor/es:Mansiroglu, Agah Koray (a) Duman, Abdullah (b)
institución:(a) Pediatric Surgery, State Hospital, Örtülüpınar Mah. İnönü, Sivas, Turkey. agahturk1986@gmail.com. (b) Radiology, State Hospital, Sivas, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cita:BMC Health Serv Res 2025 Apr 2; 25 (1) : 492.
Autor/es:Shehadeh, Anas (a) Malak, Malakeh Z (b)
institución:(a) American University of the Middle East, Egaila, P.O.Box: 220, Dasman, 15453, Kuwait. anas.shehadeh@aum.edu.kw. (b) Community Health Nursing, Faculty of Nursing, Al-Zaytoonah University of Jordan, Amman, Jordan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Epigenetic modifications of nuclear and mitochondrial DNA are associated with the disturbance of serum iron biomarkers among the metabolically unhealthy obesity school-age children.
Epigenetic modifications of nuclear and mitochondrial DNA are associated with the disturbance of serum iron biomarkers among the metabolically unhealthy obesity school-age children.
Fuente:Nutrition Journal
Extracto:
Our findings suggested that the impairments
on the epigenetic modifications of nuclear (genome-wide DNA, TF and TFR1) and
mtDNA were associated with the disturbance of serum iron biomarkers to involve in
the pathophysiology of MetS among the school-age MUO children. TRIAL
REGISTRATION: This study was approved by the Ethics Committee of Beijing
Children's Hospital affiliated to Capital Medical University (No.
IEC-C-006-A04-V.06), which was also registered at the website of
http://www.chictr.org.cn/showproj.aspx?proj=4673 (No: ChiCTR-OCH-14004900).
Claves:Iron, Metabolic syndrome, Metabolically unhealthy obesity, Methylation, Mitochondrial DNA
Cita:Nutr J 2025 Apr 2; 24 (1) : 51.
Autor/es:Xia, Lulu (a) Luo, Xin (b)
institución:(a) Department of Clinical Nutrition, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. (b) Laboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children's Ministry of Education, Beijing Children's Hospital, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, No.56 Nan-li-shi Road, Beijing, 100045, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Comparison of infant feeding practices by maternal HIV status, and associated factors, in a rural district, South Africa 2019.
Comparison of infant feeding practices by maternal HIV status, and associated factors, in a rural district, South Africa 2019.
Fuente:International Breastfeeding Journal
Extracto:
In this study population, EBF was comparably more likely among HEs
while breastfeeding beyond 12 months was more likely among HUs. Maternal marital
status, frequency of antenatal care attendance and male partner's HIV status also
influenced breastfeeding practice. Overall, there is still room for improvement
regardless of infant HIV status, requiring continued client-sensitive
strengthening of the implementation of the recommended breastfeeding practices.
Claves:Breastfeeding beyond 12 months, Exclusive breastfeeding, HIV exposed infants, Infant feeding practice, Vertical HIV transmission
Cita:Int Breastfeed J 2025 Apr 2; 20 (1) : 22.
Autor/es:Mukhula, Victoria Temwanani (a) Zunza, Moleen (b)
institución:(a) Division of Epidemiology and Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. (b) Division of Epidemiology and Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients' postchemotherapy via the AES-SDM.
Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients' postchemotherapy via the AES-SDM.
Fuente:European Journal of Medical Research
Tipo de trabajo:Metanálisis
Extracto:
This meta-analysis revealed consistent gray matter volume
alterations in ALL patients post-chemotherapy, emphasizing the need to explore
their underlying mechanisms and long-term effects on cognitive and neurological
health.
institución:(a) Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese People'S Liberation Army, Lanzhou, China. (b) Department of Pediatrics, The 940th Hospital of Joint Logistics Support Force of Chinese People'S Liberation Army, No. 333 Nanbinhe Road, Qilihe District, Lanzhou, 730050, Gansu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Nurses' nutritional care practice and associated factors for hospitalized surgical patients; the case of referral hospitals in Bahir Dar City, Ethiopia.
Nurses' nutritional care practice and associated factors for hospitalized surgical patients; the case of referral hospitals in Bahir Dar City, Ethiopia.
Fuente:Journal of Health, Population, and Nutrition
Tipo de trabajo:Guía
Extracto:
The practice of nurses in
nutritional care was low. Gender, access to nutritional information sources,
physician orders, nurses to patient ratio, knowledge, and attitude of nurses were
factors associated with their practice. Therefore; training, guideline access,
experience sharing, and increasing nursing staff is crucial to provide optimal
nutritional care for hospitalized patients.
Claves:Nursing practice, Nutritional care, Referral hospitals
institución:(a) Department of Adult Health Nursing, School of Health Science, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia. alamirewenyew66@gmail.com. (b) School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Pancreatic Status Is Not a Risk Factor for Cystic Fibrosis-Related Bone Disease.
Pancreatic Status Is Not a Risk Factor for Cystic Fibrosis-Related Bone Disease.
Fuente:Pediatric Pulmonology
Extracto:
The prevalence and severity of CFBD were not
found to correlate with pancreatic sufficiency. The similar prevalence of CFBD
between patients with PS and PI suggests that screening, and eventually
treatment, should be offered to all PwCF, irrespective of pancreatic status.
institución:(a) Kathy and Lee Graub Cystic Fibrosis Center, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. (b) School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Epidemiology and comorbidity of juvenile idiopathic arthritis in Poland- a nationwide study.
Epidemiology and comorbidity of juvenile idiopathic arthritis in Poland- a nationwide study.
Fuente:Pediatric Rheumatology Online Journal
Extracto:
This comprehensive,
nationwide study provides a contemporary estimate of JIA burden in Poland. Our
findings indicate that both the occurrence of new cases and overall burden of JIA
in the past ten years align with the lower end of projected figures for our
geographical area, especially when compared with Scandinavian nations.
Autor/es:Żuber, Zbigniew (a) Podwójcic, Krzysztof (b)
institución:(a) Department of Pediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski University, Krakow, Poland. zbyszekzuber@interia.pl. (b) Department of Analysis and Strategy, Ministry of Health, Warsaw, Poland.
Conflicto:Declarations. Ethics approval and consent to participate: Under local regulations, ethical approval is not required due to the retrospective and secondary nature of the data. Data were also anonymized prior to analysis with subgroup size > 5 cases. This analysis relies solely on data obtained from the National Health Fund electronic databases. Obtaining institutional ethical approval was not required. Data utilized for...
for this analysis was fully anonymized, which precludes the ability to reliably identify individuals. Consent for publication: Not applicable. Competing interests: none to declare.
Multimodal contrastive learning for enhanced explainability in pediatric brain tumor molecular diagnosis.
Multimodal contrastive learning for enhanced explainability in pediatric brain tumor molecular diagnosis.
Fuente:Scientific Reports
Extracto:
These enhancements can build trust in our model among radiologists, facilitating
its integration into clinical practices for more efficient tumor diagnosis.
institución:(a) Neurosciences and Mental Health Research Program, The Hospital for Sick Children, Toronto, Canada. (b) Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
How 5-ALA enlightens neurosurgery - results of a single centre study on high-grade gliomas.
How 5-ALA enlightens neurosurgery - results of a single centre study on high-grade gliomas.
Fuente:Annals of Agricultural and Environmental Medicine Aaem
Extracto:
Based on the observations, the use of 5-ALA in
surgery for high-grade gliomas allows for an increase in the extent of resection
performed and an improvement in patient prognosis. Moreover, the use of 5-ALA
shows better results for primary tumours when compared to recurrent ones
(p<0.0001 for primary gliomas).
Claves:5-ALA, Glioblastoma, Glioma, Glioma treatment, fluorescence-guided surgery
Cita:Ann Agric Environ Med 2025 Mar 25; 32 (1) : 133-141.
Autor/es:Mazurek, Marek (a) Lehman, Natalia (b)
institución:(a) Department of Neurosurgery and Paediatric Neurosurgery, Medical University, Lublin, Poland. (b) Department of Neurosurgery and Paediatric Neurosurgery, Medical University, Lublin, Poland.
