A novel flow cytometry panel to identify prognostic markers for steroid-sensitive forms of idiopathic nephrotic syndrome in childhood.

A novel flow cytometry panel to identify prognostic markers for steroid-sensitive forms of idiopathic nephrotic syndrome in childhood.

Fuente:Frontiers in Immunology

Tipo de trabajo:Estudio de cohortes

Extracto: We have set up a novel, reproducible, disease-specific flow cytometry panel that allows a comprehensive characterization of circulating lymphocytes. We found that, at disease onset, relapsing patients had significantly more transitional, CD19(+)CD27(+) memory and unswitched memory B cells and those who are at higher risk of relapse had increased circulating levels of unswitched memory B cells, independently of age. This approach can allow prediction of clinical evolution, monitoring of immunosuppression and tailored treatment in different forms of INS.

Claves:B cell, T cell, idiopathic nephrotic syndrome, lymphocyte profile, prognostic markers

Cita:Front Immunol 2024; 15 : 1379924.

Autor/es:Riganati, Martina (a)
Zotta, Federica (b)

institución:(a) Laboratory of Nephrology, Bambino Gesù Children's Hospital Scientific Institute for Research and Health Care (IRCCS), Rome, Italy.
(b) Division of Nephrology, Bambino Gesù Children's Hospital Scientific Institute for Research and Health Care (IRCCS), Rome, Italy.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1379924

PyPop: a mature open-source software pipeline for population genomics.

Fuente:Frontiers in Immunology

Extracto: Code available at: https://zenodo.org/records/10080668 and https://github.com/alexlancaster/pypop.

Claves:HLA, MHC, bioinformatics, population genomics, software

Cita:Front Immunol 2024; 15 : 1378512.

Autor/es:Lancaster, Alexander K (a)
Single, Richard M (b)

institución:(a) Amber Biology LLC, Cambridge, MA, United States.
(b) Ronin Institute, Montclair, NJ, United States.

Conflicto:Authors AL and GW are co-owners of Amber Biology LLC. Author MM is the owner of Mariani Systems LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1378512

When DNA-damage responses meet innate and adaptive immunity.

When DNA-damage responses meet innate and adaptive immunity.

Fuente:Cellular and Molecular Life Sciences Cmls

Extracto: The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.

Claves:Adaptive immunity, DNA-damage response (DDR), IFN, Innate immunity, cGAS–STING

Cita:Cell Mol Life Sci 2024 Apr 17; 81 (1) : 185.

Autor/es:Tong, Jie (a)
Song, Jiangwei (b)

institución:(a) College of Life Science, Hebei University, Baoding, 071002, China.
(b) Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.

Conflicto:The authors claim no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.1007/s00018-024-05214-2

Multicenter evaluation of complex urinary diversion for renal transplantation: outcomes of complex surgical solutions.

Multicenter evaluation of complex urinary diversion for renal transplantation: outcomes of complex surgical solutions.

Fuente:World Journal of Urology

Extracto: The mid-term kidney transplant function with complex urinary diversion appears to be comparable to transplants with regular urinary diversions. Hence, complex urinary diversion should always be considered as a surgical option, even during transplantation, if necessary.

Claves:Dialysis, Ileal conduit, Kidney transplantation, Renal insufficiency, Urinary diversion

Cita:World J Urol 2024 Apr 17; 42 (1) : 239.

Autor/es:Flegar, Luka (a)
Huber, Johannes (b)

institución:(a) Department of Urology, Philipps-University Marburg, Baldinger Street, 35043, Marburg, Germany. luka.flegar@uk-gm.de.
(b) Department of Urology, Philipps-University Marburg, Baldinger Street, 35043, Marburg, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s00345-024-04934-1

Knowledge, Attitudes, and Practices about Electronic Personal Health Records: A Cross-Sectional Study in a Region of Northern Italy.

Knowledge, Attitudes, and Practices about Electronic Personal Health Records: A Cross-Sectional Study in a Region of Northern Italy.

Fuente:Journal of Medical Systems

Extracto: Involving professionals in promoting this tool is crucial for helping patients and managing health data.

Claves:Electronic personal health records, Health data, Patient-centered care, Telemedicine, e-health

Cita:J Med Syst 2024 Apr 17; 48 (1) : 42.

Autor/es:Scaioli, Giacomo (a)
Martella, Manuela (b)

institución:(a) Department of Public Health Sciences and Paediatrics, University of Turin, Via Santena 5bis, Turin, 10126, Italy.
(b) Infection Control Unit, ASL TO3, Turin, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1007/s10916-024-02065-z

Comparing Open-Access Database and Traditional Intensive Care Studies Using Machine Learning: Bibliometric Analysis Study.

Comparing Open-Access Database and Traditional Intensive Care Studies Using Machine Learning: Bibliometric Analysis Study.

Fuente:Journal of Medical Internet Research

Tipo de trabajo:Revisión

Extracto: This study analyzed ICU research, providing valuable insights from a large number of publications. OAD studies complement TIC studies, focusing on predictive modeling, while TIC studies capture essential qualitative information. Integrating both approaches in a complementary manner is the future direction for ICU research. Additionally, natural language processing techniques offer a transformative alternative for literature review and bibliometric analysis.

Claves:BERTopic, MIMIC, Medical Information Mart for Intensive Care, critical care, eICU, machine learning, natural language processing

Cita:J Med Internet Res 2024 Apr 17; 26 : e48330.

Autor/es:Ke, Yuhe (a)
Yang, Rui (b)

institución:(a) Division of Anesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore, Singapore.
(b) Centre for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.2196/48330

Screen time, social media use, and weight-related bullying victimization: Findings from an international sample of adolescents.

Screen time, social media use, and weight-related bullying victimization: Findings from an international sample of adolescents.

Fuente:Plos One

Extracto: Country-specific and global public health and technology efforts are needed to address this burgeoning social problem.

Cita:PLoS One 2024; 19 (4) : e0299830.

Autor/es:Ganson, Kyle T (a)
Pang, Nelson (b)

institución:(a) Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada.
(b) Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299830

Family structure and the association with physical activity-Findings from 40 countries participating in the Health Behaviour in School-aged Children (HBSC) study.

Fuente:Plos One

Extracto: Family structure correlated with PA, but cross-country differences exist. The findings are relevant for the development of policies and programs to facilitate PA, especially in countries where living with one versus two parents was unfavourable. Additional country-specific research is needed to identify challenges for engaging in PA related to family structure.

Cita:PLoS One 2024; 19 (4) : e0300188.

Autor/es:Haug, Ellen (a)
Smith, Otto Robert Frans (b)

institución:(a) Department of Health Promotion and Development, University of Bergen, Bergen, Norway.
(b) Department of Teacher Education, NLA University College, Bergen, Norway.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300188

Impact of COVID-19 on acute appendicitis presentation, management and pathology findings in adult and paediatric populations.

Fuente:Plos One

Tipo de trabajo:Revisión

Extracto: Year 1 of the COVID-19 pandemic was associated with delayed presentation of acute appendicitis in adults and children. In adults, an overall reduction in appendicectomy operations, increased use of pre-operative diagnostic imaging, and fewer specimens showing simple acute appendicitis or non-diagnostic features, collectively support appropriate restriction of surgery for those patients with a more certain acute appendicitis diagnosis.

Cita:PLoS One 2024; 19 (4) : e0300357.

Autor/es:Johnston, Dorothy B (a)
Coleman, Helen G (b)

institución:(a) Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
(b) Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300357

Outcomes after cancer diagnosis in children and adult patients with congenital heart disease in Sweden

Outcomes after cancer diagnosis in children and adult patients with congenital heart disease in Sweden

Fuente:Bmj Open

Tipo de trabajo:Estudio de cohortes

Extracto: Cancer-related deaths constituted 1.8% of all mortalities across all CHD patients. Among CHD patients with cancer, 18.3% died, with cancer being the cause in 71.9% of cases. Although CHD patients have an increased cancer risk, their mortality risk post-diagnosis does not significantly differ from non-CHD patients after adjustements and exclusion of patients with genetic syndromes and transplant recipients. However, CHD patients with genetic syndromes and concurrent cancer appear to be a vulnerable group.

Claves:CARDIOLOGY, Congenital heart disease, Epidemiology, ONCOLOGY, Prognosis

Cita:BMJ Open 2024 Apr 17; 14 (4) : e083237.

Autor/es:Karazisi, Christina (a)
Dellborg, Mikael (b)

institución:(a) Department of Molecular and Clinical Medicine, University of Gothenburg, Goteborg, Sweden christina.karazisi@vgregion.se.
(b) Department of Medicine, Geriatrics and Emergency Medicine, Region Västra Götaland, Sahlgrenska University Hospital, Goteborg, Sweden.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-083237

Building CapaCITY/É for sustainable transportation: protocol for an implementation science research program in healthy cities.

Fuente:Bmj Open

Tipo de trabajo:Revisión

Extracto: A Knowledge Mobilization Hub will coordinate dissemination of findings via a website; presentations to academic, community organisations and practitioner audiences; and through peer-reviewed articles.

Claves:Health Equity, Implementation Science, PUBLIC HEALTH, QUALITATIVE RESEARCH, Safety, Surveys and Questionnaires

Cita:BMJ Open 2024 Apr 17; 14 (4) : e085850.

Autor/es:Winters, Meghan (a)
Fuller, Daniel (b)

institución:(a) Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada mwinters@sfu.ca.
(b) Department of Community Health and Epidemiology, University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2024-085850

Fetal alcohol spectrum disorder and attention deficit hyperactivity disorder stimulant trial in children: an N-of-1 pilot trial to compare stimulant to placebo (FASST): protocol.

Fuente:Bmj Open

Tipo de trabajo:Estudio aleatorizado

Extracto: TRIAL REGISTRATION NUMBER: NCT04968522.

Claves:Developmental neurology & neurodisability, Protocols & guidelines, STATISTICS & RESEARCH METHODS

Cita:BMJ Open 2024 Apr 17; 14 (4) : e071266.

Autor/es:Crichton, Alison (a)
Harris, Katrina (b)

institución:(a) Department of Paediatrics, Monash University, Clayton, Victoria, Australia ali.crichton@monash.edu.
(b) Department of Paediatrics, Monash University, Clayton, Victoria, Australia.

Conflicto:Competing interests: JN has a commercial interest in N-of-1 Hub Pty Ltd consultancy company.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2022-071266

Genetic barriers more than environmental associations explain Serratia marcescens population structure.

Genetic barriers more than environmental associations explain Serratia marcescens population structure.

Fuente:Communications Biology

Extracto: These results suggest that genetic isolation has preceded ecological adaptations in the shaping of the species diversity, an evolutionary scenario coherent with the Evolutionary Extended Synthesis.

Cita:Commun Biol 2024 Apr 17; 7 (1) : 468.

Autor/es:Sterzi, Lodovico (a)
Nodari, Riccardo (b)

institución:(a) Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center "Romeo and Enrica Invernizzi", Università Di Milano, 20157, Milan, Italy.
(b) Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center "Romeo and Enrica Invernizzi", Università Di Milano, 20157, Milan, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s42003-024-06069-w

Prevention and management of dental erosion and decay.

Prevention and management of dental erosion and decay.

Fuente:Bmc Oral Health

Extracto: This Editorial invites researchers to contribute to the collection, 'Prevention and management of dental erosion and decay'.

Claves:Dental caries, Dental erosion, Management, Prevention, Tooth decay

Cita:BMC Oral Health 2024 Apr 17; 24 (1) : 468.

Autor/es:Campus, Guglielmo (a)
Niu, John Yun (b)

institución:(a) Klinik für Zahnerhaltung, Präventiv- und Kinderzahnmedizin Zahnmedizinische Kliniken, University of Bern, Bern, Switzerland.
(b) Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.

Conflicto:The authors declare that they are Guest Editors of the Collection ‘Prevention and management of dental erosion and decay’.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12903-024-04257-y

Comment on Ombashi, van der Goes, Versnel, Khonsari, van der Molen

Comment on Ombashi, van der Goes, Versnel, Khonsari, van der Molen

Fuente:Orphanet Journal of Rare Diseases

Tipo de trabajo:Revisión sistemática

Extracto: in their research.

Claves:Cleft lip and palate, Orthodontics, Registry, Speech, Surgery

Cita:Orphanet J Rare Dis 2024 Apr 17; 19 (1) : 162.

Autor/es:Klintö, Kristina (a)
Becker, Magnus (b)

institución:(a) Department of Clinical Sciences in Lund, Lund University, Lund, Sweden. kristina.klinto@med.lu.se.
(b) Department of Otorhinolaryngology, Skåne University Hospital, Malmö, Sweden. kristina.klinto@med.lu.se.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03123-y

Detecting T-cell clonal expansions and quantifying clone survival using deep profiling of immune repertoires.

Detecting T-cell clonal expansions and quantifying clone survival using deep profiling of immune repertoires.

Fuente:Frontiers in Immunology

Extracto: We demonstrate its utility by measuring the T-cell repertoire stability in healthy donors, by quantifying the effect of donor lymphocyte infusion (DLI), and by tracking the fate of the different T-cell subsets in HSCT patients and the expansion of pathogen-specific clones in vaccinated individuals.

Claves:T cell receptor (TCR), T cell repertoire analysis, TCR sequencing, adaptive immune receptor repertoire (AIRR), clonal tracking, hematopoietic (stem) cell transplantation (HCST), immune monitoring, immune reconstitution

Cita:Front Immunol 2024; 15 : 1321603.

Autor/es:Pavlova, Anastasia V (a)
Zvyagin, Ivan V (b)

institución:(a) Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.
(b) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1321603

Somatic and Posttraumatic Stress Symptoms in Children and Adolescents in France.

Somatic and Posttraumatic Stress Symptoms in Children and Adolescents in France.

Fuente:Jama Network Open

Extracto: AND RELEVANCE: In this cross-sectional study, somatic symptoms were positively correlated with PTSS both in frequency and intensity among youths. These results suggest that the systematic screening for somatic symptoms in youths with traumatic exposure should be a routine evaluation procedure.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e247193.

Autor/es:Fernandez, Arnaud (a)
Askenazy, Florence (b)

institución:(a) Nice Pediatric Psychotrauma Center, University Department of Child and Adolescent Psychiatry, Children's Hospitals of Nice CHU-Lenval, Nice, France.
(b) CoBTek, Université Côte d'Azur, Nice, France.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.7193

Gender distribution of Top Doctors in otolaryngology-head and neck surgery.

Gender distribution of Top Doctors in otolaryngology-head and neck surgery.

Fuente:Plos One

Extracto: The percentage of women named as Top Doctors was less than the proportion of women in otolaryngology. This may be attributed to gender differences we found in fellowship type and certification. Further research into the role of otolaryngology subspecialties in selection of Top Doctors is needed to better understand gender differences.

Cita:PLoS One 2024; 19 (4) : e0300659.

Autor/es:DiNardo, Lauren A (a)
Reese, Alyssa D (b)

institución:(a) Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, New York, United States of America.
(b) Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, New York, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300659

Pathophysiology of non-cystic fibrosis bronchiectasis in children and adolescents with asthma

Fuente:Plos One

Tipo de trabajo:Revisión sistemática

Extracto: SYSTEMATIC REVIEW REGISTRATION: The systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) in July 2023 (registration number CRD42023440355).

Cita:PLoS One 2024; 19 (4) : e0294921.

Autor/es:da Silva, Natali Caroline (a)
Malagutti, Beatriz Cocato (b)

institución:(a) Postgraduate Program in Child and Adolescent Health of the School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
(b) Medical School, Pontifical Catholic University of Campinas, Campinas, São Paulo, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0294921

Paternal depression in the postpartum year and children's behaviors at age 5 in an urban U.S. birth cohort.

Fuente:Plos One

Extracto: Fathers' depression at age 1 was associated with children's externalizing behaviors at age 5, an important developmental stage when children transition to school. These findings suggest a need to identify and support fathers with depressive symptoms to promote optimal child development.

Cita:PLoS One 2024; 19 (4) : e0300018.

Autor/es:Schmitz, Kristine (a)
Jimenez, Manuel E (b)

institución:(a) Department of Pediatrics, Division of Population Health, Quality and Implementation, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, United States of America.
(b) Child Health Institute of New Jersey, Rutgers University, New Brunswick, New Jersey, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300018