Itaconic acid inhibits nontuberculous mycobacterial growth in pH dependent manner while 4-octyl-itaconic acid enhances THP-1 clearance of nontuberculous mycobacteria in vitro.

Itaconic acid inhibits nontuberculous mycobacterial growth in pH dependent manner while 4-octyl-itaconic acid enhances THP-1 clearance of nontuberculous mycobacteria in vitro.

Fuente:Plos One

Extracto: Lastly, the addition of cell-permeable 4-octyl itaconate (4-OI) to THP-1 cells enhanced NTM clearance, demonstrating a potential role for IA/itaconate in host defense against NTM infections.

Cita:PLoS One 2024; 19 (5) : e0303516.

Autor/es:Breen, Paul (a)
Zimbric, Madsen (b)

institución:(a) Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States of America.
(b) Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303516

Determinants of post-acute COVID-19 syndrome among hospitalized severe COVID-19 patients: A 2-year follow-up study.

Fuente:Plos One

Tipo de trabajo:Caso clínico

Extracto: The prevalence of post-acute COVID-19 syndrome is high, with a wide range of persistent symptoms experienced by patients. COVID-19 survivors with the identified risk factors are more susceptible to post-acute COVID-19 and require targeted monitoring and care in a multidisciplinary approach.

Cita:PLoS One 2024; 19 (5) : e0298409.

Autor/es:Elias, Tamrat Petros (a)
Gebreamlak, Tsegaye Wesenseged (b)

institución:(a) Department of Internal Medicine, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
(b) Department of Internal Medicine, Adera Medical and Surgical Center, Addis Ababa, Ethiopia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0298409

Ambient air pollution as a time-varying covariate in the survival probability of childhood cancer patients in the upper Northern Thailand.

Fuente:Plos One

Extracto: A larger-scale analytical study might uncover such relationships.

Cita:PLoS One 2024; 19 (5) : e0303182.

Autor/es:Sathitsamitphong, Lalita (a)
Chitapanarux, Imjai (b)

institución:(a) Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
(b) Northern Thai Research Group of Therapeutic Radiology and Oncology (NTRG-TRO), Divisions of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303182

Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.

Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.

Fuente:Nature Communications

Extracto: Our data should further inform and support the clinical evaluation of these three antibiotic combinations for the treatment of neonatal sepsis in areas with high rates of multidrug-resistant Gram-negative bacteria.

Cita:Nat Commun 2024 May 10; 15 (1) : 3947.

Autor/es:Kakaraskoska Boceska, Biljana (a)
Vilken, Tuba (b)

institución:(a) Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium. Biljana.KakaraskoskaBoceska@uantwerpen.be.
(b) Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.

Conflicto:The authors declare the following competing interests: J.A.B.: Research grant support to the university from Wellcome, NIHR, MRC, and the Bill & Melinda Gates Foundation who had no role in any aspect of the study or decision to publish. A.S.W. is an NIHR Senior Investigator supported by the NIHR Biomedical Research Center Oxford and core support to the MRC Clinical... Trials Unit [MC_UU_00004/05]. J.B. is an NIHR Advanced Fellow and Chief Investigator supported by grant NIHR302554 and H2020 Agreement number 965328. The remaining authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48296-z

Association between sedentary behavior and dynapenic abdominal obesity among older adults from low- and middle-income countries.

Association between sedentary behavior and dynapenic abdominal obesity among older adults from low- and middle-income countries.

Fuente:Aging Clinical and Experimental Research

Extracto: Interventions to reduce sedentary behaviour may also lead to reduction of DAO and its adverse health outcomes, especially among males, pending future longitudinal research.

Claves:Dynapenic abdominal obesity, Epidemiology, Low- and middle-income countries, Older adults, Sitting time

Cita:Aging Clin Exp Res 2024 May 11; 36 (1) : 109.

Autor/es:Smith, Lee (a)
López Sánchez, Guillermo F (b)

institución:(a) Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
(b) Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain. gfls@um.es.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s40520-024-02763-1

Distinct clinical features of transplanted children with Parvovirus B19 infection.

Distinct clinical features of transplanted children with Parvovirus B19 infection.

Fuente:Virology Journal

Tipo de trabajo:Revisión

Extracto: Compared with the published data of transplanted adults, transplanted children displayed distinct clinical features upon PVB19 infection, including lower PVB19 IgM/IgG positive rates, more graft dysfunction, and broader damage on hematopoietic cell lines, which was even more prominent in HSCT recipients, thus should be of greater concern.

Claves:Children, Clinical features, Parvovirus B19, Transplantation

Cita:Virol J 2024 May 10; 21 (1) : 108.

Autor/es:Jia, Ran (a)
Cao, Lingfeng (b)

institución:(a) Department of Clinical Laboratory, Children's Hospital of Fudan University & National Children's Medical Center, Shanghai, 201102, China.
(b) Department of Clinical Laboratory, Children's Hospital of Fudan University & National Children's Medical Center, Shanghai, 201102, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12985-024-02380-4

Determination of birth prevalence of sickle cell disease using point of care test HemotypeSC™ at Rundu Hospital, Namibia.

Determination of birth prevalence of sickle cell disease using point of care test HemotypeSC™ at Rundu Hospital, Namibia.

Fuente:Bmc Pediatrics

Extracto: This study is the first to measure HbS gene carriage at birth using HemotypeSC point-of-care testing in Namibia. There was a moderate prevalence of sickle cell traits but no SCD. This baseline study may provide the foundation for larger epidemiological surveys to map HbS gene carriage in Namibia to provide evidence for policy makers to fashion appropriate SCD newborn screening services.

Claves:Hemotype SC™, Malaria prone region, Newborn screening, Sickle cell disease

Cita:BMC Pediatr 2024 May 10; 24 (1) : 323.

Autor/es:Mano, Runyararo Mashingaidze (a)
Kuona, Patience (b)

institución:(a) Department of Maternal & Child Health, Division of Paediatrics, School of Medicine, Faculty of Health Sciences and Veterinary Medicine, University of Namibia Hage Geingob Campus, Bach Street, Windhoek, Namibia. mashingaidzemano2003@gmail.com.
(b) Department of Child, Adolescent and Women's Health, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12887-024-04805-z

Recommended homemade fluid utilization for the treatment of diarrhea and associated factors among children under five in sub-Saharan African countries: a multilevel analysis of the recent demographic and health survey.

Fuente:Bmc Pediatrics

Extracto: The overall recommended homemade fluid utilization for the treatment of diarrhea was low. Individual and community-level variables were associated with recommended homemade fluid utilization for the treatment of diarrhea. Therefore, special consideration should be given to rural dwellers and caregivers who have three and below children. Furthermore, better to strengthen the antenatal care service, mother/caregiver education, and father's education to enhance recommended homemade fluid utilization for the treatment of diarrhea.

Claves:Children under-five, Diarrhea, Homemade fluid, Sub-saharan Africa, Utilization

Cita:BMC Pediatr 2024 May 10; 24 (1) : 322.

Autor/es:Workneh, Belayneh Shetie (a)
Mekonen, Enyew Getaneh (b)

institución:(a) Department of Emergency and Critical Care Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. belay2319@gmail.com.
(b) Department of Surgical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Conflicto:The authors declare that they have no conflict of interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12887-024-04810-2

Prescription drug monitoring programs and prescription pain medication misuse among U.S. high school students-2019.

Prescription drug monitoring programs and prescription pain medication misuse among U.S. high school students-2019.

Fuente:Bmc Public Health

Extracto: None of the five PDMP dimensions were associated with lower prescription pain medication misuse, however further research is needed, especially as new YRBS data become available.

Claves:Prescription drug monitoring programs, Prescription pain medication misuse, Youth risk behavior survey

Cita:BMC Public Health 2024 May 10; 24 (1) : 1276.

Autor/es:Liu, Kevin (a)
Benedetti, Marco (b)

institución:(a) Center for Injury Research and Policy, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
(b) Center for Injury Research and Policy, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18698-1

Serum stromal cell-derived factor-1 concentrations are increased and associated with nonalcoholic fatty liver disease in children with obesity.

Serum stromal cell-derived factor-1 concentrations are increased and associated with nonalcoholic fatty liver disease in children with obesity.

Fuente:Bmc Endocrine Disorders

Extracto: These results suggest that SDF-1 levels are elevated in obese children and are associated with NAFLD, indicating that SDF-1 may play a role in the development of childhood obesity and metabolic disorders.

Claves:Childhood obesity, Nonalcoholic fatty liver disease, SDF-1

Cita:BMC Endocr Disord 2024 May 10; 24 (1) : 67.

Autor/es:Liu, Yuesheng (a)
Hao, Lijun (b)

institución:(a) Department of Pediatrics, The Second Affiliated Hospital of Xi an Jiaotong University, Xiwu Road, Xi ', Shaanxi, 710000, People's Republic of China.
(b) Neonatal Department, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12902-024-01597-2

Comparison of dmft and behavior rating scores between children with systemic disease and healthy children at the first dental visit.

Comparison of dmft and behavior rating scores between children with systemic disease and healthy children at the first dental visit.

Fuente:Bmc Oral Health

Extracto: The presence of chronic disease in children appeared to affect the cooperation negatively at the first dental visit compared to healthy controls, however, it did not affect the oral health negatively. Having a negative behavior score or SD did not necessitate the use of GA/S for dental treatment.

Claves:Children, Chronic disease, Cooperation, Oral health

Cita:BMC Oral Health 2024 May 10; 24 (1) : 548.

Autor/es:Erbas Unverdi, Gizem (a)
Ozgur, Beste (b)

institución:(a) Department of Pediatric Dentistry, Faculty of Dentistry, Hacettepe University, 06100, Sihhiye, Ankara, Turkey. erbasgizem@gmail.com.
(b) Department of Pediatric Dentistry, Faculty of Dentistry, Hacettepe University, 06100, Sihhiye, Ankara, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12903-024-04285-8

Left knee septic monoarthritis in a pediatric patient due to shewanella putrefaciens

Left knee septic monoarthritis in a pediatric patient due to shewanella putrefaciens

Fuente:Annals of Clinical Microbiology and Antimicrobials

Tipo de trabajo:Revisión

Extracto: This case highlights the bacteriological and clinical characteristics, as well as the antibiogram, of Shewanella spp. Given the recent increase in notifications of Shewanella infections, predominantly by S. algae and S. putrefaciens, it is essential to consider these pathogens in patients with a history of contact with bodies of water. Special attention must be paid to their resistance patterns in patient management to prevent the development of intrinsic antimicrobial resistance.

Claves:Shewanella putrefaciens, Colombia, Pediatrics, Penetrating wound, Septic arthritis

Cita:Ann Clin Microbiol Antimicrob 2024 May 10; 23 (1) : 43.

Autor/es:Madrid, Nathalie Yepes (a)
Mejia, Luis Fernando (b)

institución:(a) Pediatric specialty resident, Universidad Libre Sectional Cali, Valle del Cauca, Colombia. nathalieyepesmadrid@yahoo.com.
(b) Pediatrics Specialty Research Group (GRINPED), Valle del Cauca, Colombia. nathalieyepesmadrid@yahoo.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12941-024-00702-6

Short developmental milestone risk assessment tool to identify Duchenne muscular dystrophy in primary care.

Short developmental milestone risk assessment tool to identify Duchenne muscular dystrophy in primary care.

Fuente:Orphanet Journal of Rare Diseases

Tipo de trabajo:Estudio clínico

Extracto: The majority of boys (79%) with DMD can be identified between 12 and 36 months of age with this tool. It increases the initial a priori risk of DMD from 1 in 5,000 to approximately 1 in 268 boys. We expect that other neuromuscular disorders and disabilities can also be found with this tool.

Claves:Child Development, Developmental Delay, Early Childhood Development, Motor skills, Pediatrics; neuromuscular disorder

Cita:Orphanet J Rare Dis 2024 May 10; 19 (1) : 192.

Autor/es:van Dommelen, Paula (a)
van Dijk, Oisín (b)

institución:(a) Department of Child Health, The Netherlands Organization for Applied Scientific Research TNO, Leiden, The Netherlands. Paula.vanDommelen@tno.nl.
(b) Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03208-8

(2,6-Dimethylphenyl)arsonic Acid Induces Apoptosis through the Mitochondrial Pathway, Downregulates XIAP, and Overcomes Multidrug Resistance to Cytostatic Drugs in Leukemia and Lymphoma Cells In Vitro.

(2,6-Dimethylphenyl)arsonic Acid Induces Apoptosis through the Mitochondrial Pathway, Downregulates XIAP, and Overcomes Multidrug Resistance to Cytostatic Drugs in Leukemia and Lymphoma Cells In Vitro.

Fuente:International Journal of Molecular Sciences

Extracto: Due to the selective apoptosis induction, the synergistic effects with common anti-cancer drugs, and the ability to overcome multidrug resistance in vitro, As2 represents a promising candidate for further preclinical investigations with respect to refractory malignancies.

Claves:XIAP (x-linked inhibitor of apoptosis protein), apoptosis, arsenic, cancer chemotherapy, leukemia, lymphoma, mitochondrial pathway, multidrug resistance, synergy

Cita:Int J Mol Sci 2024 Apr 26; 25 (9)

Autor/es:Wilke, Nathalie (a)
Frias, Corazon (b)

institución:(a) Department of Pediatric Hematology/Oncology, Children's Hospital Cologne, Amsterdamer Straße 59, 50735 Cologne, Germany.
(b) Department of Pediatric Hematology/Oncology, Children's Hospital Cologne, Amsterdamer Straße 59, 50735 Cologne, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094713

Exosomes Secreted by Wharton's Jelly-Derived Mesenchymal Stem Cells Promote the Ability of Cell Proliferation and Migration for Keratinocyte.

Fuente:International Journal of Molecular Sciences

Extracto: Exploring the various components of AD-MSC and WJ-MSC exosomes can aid in their different clinical applications.

Claves:Wharton’s jelly mesenchymal stem cell, adipose tissue mesenchymal stem cell, exosome, fibrinogen beta chain, iTRAQ

Cita:Int J Mol Sci 2024 Apr 26; 25 (9)

Autor/es:Yu, Hong-Ren (a)
Huang, Hsin-Chun (b)

institución:(a) Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833401, Taiwan.
(b) Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833401, Taiwan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094758

Host RNA Expression Signatures in Young Infants with Urinary Tract Infection: A Prospective Study.

Fuente:International Journal of Molecular Sciences

Extracto: Our results indicate a need for further investigation and consideration of UTI in young infants before implementing host RNA expression signatures in clinical practice.

Claves:host RNA expression signatures, transcriptomics, urinary tract infection, young infants

Cita:Int J Mol Sci 2024 Apr 29; 25 (9)

Autor/es:Dungu, Kia Hee Schultz (a)
Carlsen, Emma Louise Malchau (b)

institución:(a) Department of Pediatrics & Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.
(b) Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, Denmark.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094857

The Evolving Landscape of Flowcytometric Minimal Residual Disease Monitoring in B-Cell Precursor Acute Lymphoblastic Leukemia.

Fuente:International Journal of Molecular Sciences

Extracto: Future directions involve integrating artificial intelligence, further automation, and exploring multicolor spectral flow cytometry to standardize MRD assessment and enhance diagnostic and prognostic robustness of MRD diagnostics in BCP-ALL.

Claves:B-cell precursor acute lymphoblastic leukemia, automated analysis, flow cytometry, immunotherapy, machine learning, minimal residual disease, next-generation flow cytometry

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Verbeek, Martijn W C (a)
van der Velden, Vincent H J (b)

institución:(a) Laboratory for Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
(b) Laboratory for Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094881

A Randomized Controlled Cluster Trial of an Obesity Prevention Program for Children with Special Health Care Needs: Methods and Implications.

A Randomized Controlled Cluster Trial of an Obesity Prevention Program for Children with Special Health Care Needs: Methods and Implications.

Fuente:Nutrients

Extracto: CCCs are an ideal setting for targeting CSHCN for obesity prevention efforts as they provide an opportunity to address modifiable risk factors.

Claves:children, early childhood, obesity, prevention, special health care needs

Cita:Nutrients 2024 Apr 25; 16 (9)

Autor/es:Natale, Ruby (a)
Schladant, Michelle (b)

institución:(a) Mailman Center for Child Development, Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33136, USA.
(b) Mailman Center for Child Development, Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33136, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091274

The Benefits of the Mediterranean Diet on Inflamm-Aging in Childhood Obesity.

Fuente:Nutrients

Tipo de trabajo:Revisión

Extracto: Future high-quality intervention studies are necessary to elucidate the specific impact of the MD on inflammation in diverse pediatric populations with obesity and associated comorbidities.

Claves:Mediterranean diet, childhood obesity, children, inflamm-aging, nutrition, pediatric

Cita:Nutrients 2024 Apr 25; 16 (9)

Autor/es:Calcaterra, Valeria (a)
Verduci, Elvira (b)

institución:(a) Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
(b) Pediatric Department, Buzzi Children's Hospital, 20154 Milan, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091286

Impact of Serious Games on Body Composition, Physical Activity, and Dietary Change in Children and Adolescents

Fuente:Nutrients

Tipo de trabajo:Revisión sistemática

Extracto: Serious games show potential as tools for overweight/obesity control among children and adolescents but may require longer intervention to sustain its effect.

Claves:adolescents, body composition, children, dietary change, physical activity, serious game

Cita:Nutrients 2024 Apr 26; 16 (9)

Autor/es:Liu, Mingchang (a)
Guan, Xinyue (b)

institución:(a) Institute for Hospital Management, School of Medicine, Tsinghua University, Beijing 100084, China.
(b) Institute for Hospital Management, School of Medicine, Tsinghua University, Beijing 100084, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091290